DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung Jun | - |
dc.contributor.author | Yeo, Ki Baek | - |
dc.contributor.author | Lee, Dohoon | - |
dc.contributor.author | Hwang, Dong Soo | - |
dc.contributor.author | Jun, Sang Ho | - |
dc.date.accessioned | 2024-03-06T02:20:41Z | - |
dc.date.available | 2024-03-06T02:20:41Z | - |
dc.date.created | 2024-03-01 | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 1226-8372 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/121412 | - |
dc.description.abstract | Xenograft bone granules are bone graft materials that are widely used to reconstruct bone tissue in clinical practice, and their clinical success requires aggregation with a biocompatible binder. While the catechol mussel bioadhesive has been used as a key universal biomedical glue moiety, the thiols in mussel adhesive proteins have recently been shown to play key roles in mussel wet adhesion. Here, pentaerythritol tris(3-mercaptopropionate)-di-catechol (PETMP-di-catechol), a catechol- and thiol-containing binder molecule that mimics mussel adhesive proteins, was used to aggregate xenograft bone granules and reconstruct bone tissue. The PETMP-di-catechol-aggregated xenograft bone granules were most resistive to compression stress when both the catechol and thiol moieties in PETMP-di-catechol were chemically oxidized with sodium periodate. The xenograft bone granules aggregated with the oxidized PETMP-di-catechol exhibited enhanced osteogenic cellular behavior in vitro and in vivo in a rat calvarial defect model, compared to the control group treated with catechol-conjugated chitosan, a catechol-containing polymer binder devoid of thiol moieties. Hence, the thiol-containing catechol-functionalized binder exhibits improved bone tissue reconstruction properties by mimicking mussel wet adhesion. In addition, our study suggests that PETMP-di-catechol is a potential biocompatible bone binder for use in clinical settings. © The Author(s), under exclusive licence to The Korean Society for Biotechnology and Bioengineering and Springer-Verlag GmbH Germany, part of Springer Nature 2024. | - |
dc.language | English | - |
dc.publisher | 한국생물공학회 | - |
dc.relation.isPartOf | Biotechnology and Bioprocess Engineering | - |
dc.title | Catechol- and thiol-containing binder that aggregates granular xenografts in reconstructed bone defects by mimicking mussel wet adhesion | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12257-024-00025-5 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Biotechnology and Bioprocess Engineering | - |
dc.identifier.wosid | 001169673300001 | - |
dc.citation.title | Biotechnology and Bioprocess Engineering | - |
dc.contributor.affiliatedAuthor | Lee, Dohoon | - |
dc.contributor.affiliatedAuthor | Hwang, Dong Soo | - |
dc.identifier.scopusid | 2-s2.0-85185465103 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | kci | - |
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