DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서해영 | - |
dc.date.accessioned | 2024-05-10T16:36:19Z | - |
dc.date.available | 2024-05-10T16:36:19Z | - |
dc.date.issued | 2024 | - |
dc.identifier.other | OAK-2015-10392 | - |
dc.identifier.uri | http://postech.dcollection.net/common/orgView/200000733149 | ko_KR |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/123344 | - |
dc.description | Master | - |
dc.description.abstract | The gut microbiota plays a vital role in host health and disease, with dysbiosis being associated with various illnesses, such as cancer. Gut microbiota also impact the effectiveness of anti-tumor therapeutics, including immune checkpoint blockades. Macrophage galactose/N-acetyl- galactosamine (Gal/GalNAc)-specific lectin-2 (MGL-2) belongs to C-type lectin receptors (CLRs) that are expressed on mononuclear phagocytic cell and regulates adaptive immune responses to tumor cells. MGL-2 interacts with the GalNAc antigen, found in tumor cells, contributing to tumor progression and impacting patient survival. Bacterial cell walls display diverse glycan structures, making them a target for CLRs. MGL-2 also recognize the bacterial surface glycans of various pathogenic and commensal microbes in the intestine and skin. However, it remains unclear whether MGL-2-mediated signaling derived from gut microbes plays a role in tumor progression. Here, I investigated the impact of MGL-2 deficiency on tumor progression in solid and colitis-associated colorectal tumor models. I revealed that MGL-2 deficiency significantly accelerated tumor growth, which is associated with reduced tumor infiltration of CD8+ T cells and impaired cytokine production. Notably, antibiotics treatment effectively ameliorated the facilitated tumor growth observed in MGL-2-deficient mice. Furthermore, our study identified alterations in the gut microbiota composition in MGL-2 deficient mice. These results highlight the role of MGL-2 in the complex interplay between the immune response and the gut microbiota in colorectal cancer progression. | - |
dc.language | eng | - |
dc.publisher | 포항공과대학교 | - |
dc.title | The effect of MGL-2 C-type lectin receptor deficiency and the associated gut microbiota dysbiosis on tumor progression | - |
dc.title.alternative | MGL-2 수용체의 부재와 이와 연관된 장내 미생물 불균형이 종양 증식에 미치는 영향에 대한 연구 | - |
dc.type | Thesis | - |
dc.contributor.college | 생명과학과 | - |
dc.date.degree | 2024- 2 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.