DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sharma, Garima | - |
dc.contributor.author | Sharma, Amit | - |
dc.contributor.author | Kim, Inhae | - |
dc.contributor.author | Cha, Dong Gon | - |
dc.contributor.author | Kim, Somi | - |
dc.contributor.author | Park, Eun Seo | - |
dc.contributor.author | Noh, Jae Gyun | - |
dc.contributor.author | Lee, Juhee | - |
dc.contributor.author | Ku, Ja Hyeon | - |
dc.contributor.author | Choi, Yoon Ha | - |
dc.contributor.author | Kong, JungHo | - |
dc.contributor.author | Lee, Haena | - |
dc.contributor.author | Ko, Haeun | - |
dc.contributor.author | Lee, Juhun | - |
dc.contributor.author | Notaro, Anna | - |
dc.contributor.author | Hong, Seol Hee | - |
dc.contributor.author | Rhee, Joon Haeng | - |
dc.contributor.author | Kim, Sang Geon | - |
dc.contributor.author | De Castro, Cristina | - |
dc.contributor.author | Molinaro, Antonio | - |
dc.contributor.author | Shin, Kunyoo | - |
dc.contributor.author | Kim, Sanguk | - |
dc.contributor.author | Kim, Jong Kyoung | - |
dc.contributor.author | Rudra, Dipayan | - |
dc.contributor.author | Im, Sin-Hyeog | - |
dc.date.accessioned | 2024-05-29T00:40:33Z | - |
dc.date.available | 2024-05-29T00:40:33Z | - |
dc.date.created | 2024-05-24 | - |
dc.date.issued | 2024-05 | - |
dc.identifier.issn | 1529-2908 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/123517 | - |
dc.description.abstract | Here the authors show that a heteropolysaccharide from a commensal bacteria commonly found in the Korean food kimchi is able to bolster antitumor immune responses by instructing tumor-associated macrophages to release lipocalin-2, which sequesters iron away from tumor cells contributing to the immune response to attack these cells. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2024.. Innate immune cells generate a multifaceted antitumor immune response, including the conservation of essential nutrients such as iron. These cells can be modulated by commensal bacteria; however, identifying and understanding how this occurs is a challenge. Here we show that the food commensal Lactiplantibacillus plantarum IMB19 augments antitumor immunity in syngeneic and xenograft mouse tumor models. Its capsular heteropolysaccharide is the major effector molecule, functioning as a ligand for TLR2. In a two-pronged manner, it skews tumor-associated macrophages to a classically active phenotype, leading to generation of a sustained CD8+ T cell response, and triggers macrophage ‘nutritional immunity’ to deploy the high-affinity iron transporter lipocalin-2 for capturing and sequestering iron in the tumor microenvironment. This process induces a cycle of tumor cell death, epitope expansion and subsequent tumor clearance. Together these data indicate that food commensals might be identified and developed into ‘oncobiotics’ for a multi-layered approach to cancer therapy. © The Author(s), under exclusive licence to Springer Nature America, Inc. 2024. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | Nature Immunology | - |
dc.title | A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41590-024-01816-x | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Nature Immunology, v.25, no.5, pp.790 - 801 | - |
dc.identifier.wosid | 001208246800002 | - |
dc.citation.endPage | 801 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 790 | - |
dc.citation.title | Nature Immunology | - |
dc.citation.volume | 25 | - |
dc.contributor.affiliatedAuthor | Cha, Dong Gon | - |
dc.contributor.affiliatedAuthor | Kim, Somi | - |
dc.contributor.affiliatedAuthor | Park, Eun Seo | - |
dc.contributor.affiliatedAuthor | Noh, Jae Gyun | - |
dc.contributor.affiliatedAuthor | Lee, Juhee | - |
dc.contributor.affiliatedAuthor | Choi, Yoon Ha | - |
dc.contributor.affiliatedAuthor | Kong, JungHo | - |
dc.contributor.affiliatedAuthor | Lee, Haena | - |
dc.contributor.affiliatedAuthor | Ko, Haeun | - |
dc.contributor.affiliatedAuthor | Lee, Juhun | - |
dc.contributor.affiliatedAuthor | Kim, Sanguk | - |
dc.contributor.affiliatedAuthor | Kim, Jong Kyoung | - |
dc.contributor.affiliatedAuthor | Rudra, Dipayan | - |
dc.contributor.affiliatedAuthor | Im, Sin-Hyeog | - |
dc.identifier.scopusid | 2-s2.0-85191327803 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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