DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Yong Bok | - |
dc.contributor.author | Ko, Ara | - |
dc.contributor.author | Shin, Duckhyang | - |
dc.contributor.author | Kim, Junyoung | - |
dc.contributor.author | Suh, You Suk | - |
dc.contributor.author | Na, Juyoung | - |
dc.contributor.author | Ryu, Ji In | - |
dc.contributor.author | Lee, Suyeon | - |
dc.contributor.author | Oh, Min Ji | - |
dc.contributor.author | Sung, Young Chul | - |
dc.date.accessioned | 2024-06-20T08:00:46Z | - |
dc.date.available | 2024-06-20T08:00:46Z | - |
dc.date.created | 2023-08-29 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/123698 | - |
dc.description.abstract | Waning vaccine-induced immunity, coupled with the emergence of SARS-CoV-2 variants, has inspired the widespread implementation of COVID-19 booster vaccinations. Here, we evaluated the potential of the GX-19N DNA vaccine as a heterologous booster to enhance the protective immune response to SARS-CoV-2 in mice primed with either an inactivated virus particle (VP) or an mRNA vaccine. We found that in the VP-primed condition, GX-19N enhanced the response of both vaccine-specific antibodies and cross-reactive T Cells to the SARS-CoV-2 variant of concern (VOC), compared to the homologous VP vaccine prime-boost. Under the mRNA-primed condition, GX-19N induced higher vaccine-induced T Cell responses but lower antibody responses than the homologous mRNA vaccine prime-boost. Furthermore, the heterologous GX-19N boost induced higher S-specific polyfunctional CD4(+) and CD8(+) T cell responses than the homologous VP or mRNA prime-boost vaccinations. Our results provide new insights into booster vaccination strategies for the management of novel COVID-19 variants. | - |
dc.language | English | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.relation.isPartOf | International Journal of Molecular Sciences | - |
dc.title | Potentiating the Cross-Reactive IFN-gamma T Cell and Polyfunctional T Cell Responses by Heterologous GX-19N DNA Booster in Mice Primed with Either a COVID-19 mRNA Vaccine or Inactivated Vaccine | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms24119753 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.24, no.11 | - |
dc.identifier.wosid | 001004672700001 | - |
dc.citation.number | 11 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 24 | - |
dc.contributor.affiliatedAuthor | Sung, Young Chul | - |
dc.identifier.scopusid | 2-s2.0-85161864295 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TH1 | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | DNA vaccine | - |
dc.subject.keywordAuthor | mRNA vaccine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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