DC Field | Value | Language |
---|---|---|
dc.contributor.author | Roh, Tae-Young | - |
dc.date.accessioned | 2024-06-20T08:02:05Z | - |
dc.date.available | 2024-06-20T08:02:05Z | - |
dc.date.created | 2023-09-13 | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1064-3745 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/123703 | - |
dc.description.abstract | Different from the canonical right-handed B-DNA, a left-handed Z-DNA forms an alternating syn- and anti-base conformations along the double-stranded helix under physiological conditions. Z-DNA structure plays a role in transcriptional regulation, chromatin remodeling, and genome stability. To understand the biological function of Z-DNA and map the genome-wide Z-DNA-forming sites (ZFSs), a ChIP-Seq strategy is applied, which is a combination of chromatin immunoprecipitation (ChIP) and high-throughput DNA sequencing analysis. Cross-linked chromatin is sheared and its fragments associated with Z-DNA-binding proteins are mapped onto the reference genome sequence. The global information of ZFSs positioning can provide a useful resource for better understanding of DNA structure-dependent biological mechanism. | - |
dc.language | English | - |
dc.publisher | Humana Press Inc. | - |
dc.relation.isPartOf | Methods in Molecular Biology | - |
dc.title | ChIP-Seq Strategy to Identify Z-DNA-Forming Sequences in the Human Genome | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/978-1-0716-3084-6_12 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Methods in Molecular Biology, v.2651, pp.167 - 177 | - |
dc.citation.endPage | 177 | - |
dc.citation.startPage | 167 | - |
dc.citation.title | Methods in Molecular Biology | - |
dc.citation.volume | 2651 | - |
dc.contributor.affiliatedAuthor | Roh, Tae-Young | - |
dc.identifier.scopusid | 2-s2.0-85149944124 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Book Chapter | - |
dc.subject.keywordAuthor | ChIP-Seq | - |
dc.subject.keywordAuthor | Z-DNA | - |
dc.subject.keywordAuthor | Z-DNA-binding domain | - |
dc.subject.keywordAuthor | Z-DNA-forming site | - |
dc.description.journalRegisteredClass | scopus | - |
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