Vesiclepedia: a compendium for exracellular vesicles with continous community annotation
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- Title
- Vesiclepedia: a compendium for exracellular vesicles with continous community annotation
- Authors
- Hina Kalra; Richard J Simpson; Hong Ji; Elena Aikawa; Peter Altevogt; Philip Askenase; Vincent C Bond; Francesc E Borràs; Xandra Breakefield; Vivian Budnik; Edit Buzas; Giovanni Camussi; Aled Clayton; Emanuele Cocucci; Juan M Falcon-Perez; Susanne Gabrielsson; Gho, YS; Dwijendra Gupta; Harsha, HC; An Hendrix; Andrew F Hill; Jameel M Inal; Guido Jenster; Kramer-Albers, EM; Sai Kiang Lim; Alicia Llorente; Jan Lötvall; Antonio Marcilla; Lucia Mincheva-Nilsson; Irina Nazarenko; Rienk Nieuwland; , R; Akhilesh Pandey; Tushar Patel; Melissa G Piper; Stefano Pluchino; TS Keshava Prasad; Lawrence Rajendran; Graca Raposo; Michel Record; Gavin E Reid; Francisco Sánchez-Madrid; Raymond M Schiffelers; Sanchez-Madrid, F; Allan Stensballe; Willem Stoorvogel; Douglas Taylor; Clotilde Thery; Stoorvogel, W; Bas WM van Balkom; Jesús Vázquez; Michel Vidal; Marca HM Wauben; María Yáñez-Mó; Margot Zoeller; Suresh Mathivanan; Yanez-Mo, M; Zoeller, M; Mathivanan, S
- Date Issued
- 2012-12
- Publisher
- PUBLIC LIBRARY SCIENCE
- Abstract
- Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into their microenvironment. Recent studies have elucidated the role of EVs in intercellular communication, pathogenesis, drug, vaccine and gene-vector delivery, and as possible reservoirs of biomarkers. These findings have generated immense interest, along with an exponential increase in molecular data pertaining to EVs. Here, we describe Vesiclepedia, a manually curated compendium of molecular data (lipid, RNA, and protein) identified in different classes of EVs from more than 300 independent studies published over the past several years. Even though databases are indispensable resources for the scientific community, recent studies have shown that more than 50% of the databases are not regularly updated. In addition, more than 20% of the database links are inactive. To prevent such database and link decay, we have initiated a continuous community annotation project with the active involvement of EV researchers. The EV research community can set a gold standard in data sharing with Vesiclepedia, which could evolve as a primary resource for the field.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/12631
- DOI
- 10.1371/JOURNAL.PBIO.1001450
- ISSN
- 1545-7885
- Article Type
- Article
- Citation
- PLOS BIOLOGY, vol. 10, no. 12, page. E1001450, 2012-12
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