DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, CH | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2015-06-25T03:24:17Z | - |
dc.date.available | 2015-06-25T03:24:17Z | - |
dc.date.created | 2013-02-05 | - |
dc.date.issued | 2012-09-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | 2015-OAK-0000026326 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/12665 | - |
dc.description.abstract | Phosphorylation of histone H3 on Ser-10 is regarded as an epigenetic mitotic marker and is tightly correlated with chromosome condensation during both mitosis and meiosis. However, it was also reported that histone H3 Ser-10 phosphorylation occurs when cells are exposed to various death stimuli, suggesting a potential role in the regulation of apoptosis. Here we report that histone H3 Ser-10 phosphorylation is mediated by the pro-apoptotic kinase protein kinase C (PKC) delta during apoptosis. We observed that PKC delta robustly phosphorylates histone H3 on Ser-10 both in vitro and in vivo. Ectopic expression of catalytically active PKC delta efficiently induces condensed chromatin structure in the nucleus. We also discovered that activation of PKC delta is required for histone H3 Ser-10 phosphorylation after treatment with DNA damaging agents during apoptosis. Collectively, these findings suggest that PKC delta is the kinase responsible for histone H3 Ser-10 phosphoryation during apoptosis and thus contributes to chromatin condensation together with other apoptosis-related histone modifications. As a result, histone H3 Ser-10 phosphorylation can be designated a new 'apoptotic histone code' mediated by PKC delta. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Apoptotic Phosphorylation of Histone H3 on Ser-10 by Protein Kinase C delta | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | en_US |
dc.identifier.doi | 10.1371/JOURNAL.PONE.0044307 | - |
dc.author.google | Park, CH | en_US |
dc.author.google | Kim, KT | en_US |
dc.relation.volume | 7 | en_US |
dc.relation.issue | 9 | en_US |
dc.contributor.id | 10104775 | en_US |
dc.relation.journal | PLOS ONE | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.7, no.9 | - |
dc.identifier.wosid | 000308738500046 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.number | 9 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-84866340674 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 18 | - |
dc.description.scptc | 16 | * |
dc.date.scptcdate | 2018-06-152 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PKC-DELTA | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CHROMATIN | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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