DC Field | Value | Language |
---|---|---|
dc.contributor.author | Doh, J | - |
dc.contributor.author | Irvine, DJ | - |
dc.date.accessioned | 2015-06-25T03:27:13Z | - |
dc.date.available | 2015-06-25T03:27:13Z | - |
dc.date.created | 2009-08-20 | - |
dc.date.issued | 2006-04-11 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.other | 2015-OAK-0000018007 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/12738 | - |
dc.description.abstract | T cells are activated by recognition of foreign peptides displayed on the surface of antigen presenting cells (APCs), an event that triggers assembly of a complex microscale structure at the T cell-APC interface known as the immunological synapse (IS). It remains unresolved whether the unique physical structure of the synapse itself impacts the functional response of T cells, independent of the quantity and quality of ligands encountered by the T cell. As a first step toward addressing this question, we created multicomponent protein surfaces presenting lithographically defined patterns of tethered T cell receptor (TCR) ligands (anti-CD3 "activation sites") surrounded by a field of tethered intercellular adhesion molecule-1 (ICAM-1), as a model substrate on which T cells could be seeded to mimic T cell-APC interactions. CD4(+) T cells seeded on these surfaces polarized and migrated; on contact with activation sites, T cells assembled an IS with a structure modulated by the physical pattern of ligand encountered. On surfaces patterned with focal spots of TCR ligand, T cells stably interacted with activation sites, proliferated, and secreted cytokines. In contrast, T cells interacting with activation sites patterned to preclude centralized clustering of TCR ligand failed to form stable contacts with activation sites, exhibited aberrant PKC-theta clustering in a fraction of cells, and had significantly reduced production of IFN-gamma. These results suggest that focal clustering of TCR ligand characteristic of the "mature" IS may be required under some conditions for full T cell activation. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | IMMUNOLOGICAL SYNAPSE ARRAYS: PATTERNED PROTEIN SURFACES THAT MODULATE IMMUNOLOGICAL SYNAPSE STRUCTURE FORMATION IN T CELLS | - |
dc.type | Article | - |
dc.contributor.college | 시스템생명공학부 | en_US |
dc.identifier.doi | 10.1073/PNAS.0509404 | - |
dc.author.google | Doh, J | en_US |
dc.author.google | Irvine, DJ | en_US |
dc.relation.volume | 103 | en_US |
dc.relation.issue | 15 | en_US |
dc.relation.startpage | 5700 | en_US |
dc.relation.lastpage | 5705 | en_US |
dc.contributor.id | 10189091 | en_US |
dc.relation.journal | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.103, no.15, pp.5700 - 5705 | - |
dc.identifier.wosid | 000236896200014 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 5705 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 5700 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 103 | - |
dc.contributor.affiliatedAuthor | Doh, J | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 117 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ADHESION MOLECULE-1 | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | DIVERSITY | - |
dc.subject.keywordPlus | BILAYERS | - |
dc.subject.keywordPlus | CD3-ZETA | - |
dc.subject.keywordPlus | SHAPE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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