DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, JS | - |
dc.contributor.author | Kim, Y | - |
dc.contributor.author | Bhin, J | - |
dc.contributor.author | Shin, HJR | - |
dc.contributor.author | Nam, HJ | - |
dc.contributor.author | Lee, SH | - |
dc.contributor.author | Yoon, JB | - |
dc.contributor.author | Binda, O | - |
dc.contributor.author | Gozani, O | - |
dc.contributor.author | Hwang, D | - |
dc.contributor.author | Baek, SH | - |
dc.date.accessioned | 2015-06-25T03:28:11Z | - |
dc.date.available | 2015-06-25T03:28:11Z | - |
dc.date.created | 2011-09-20 | - |
dc.date.issued | 2011-08-16 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.other | 2015-OAK-0000024268 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/12761 | - |
dc.description.abstract | Pontin is a chromatin remodeling factor that possesses both ATPase and DNA helicase activities. Although Pontin is frequently overexpressed in human cancers of various types and implicated in oncogenic functions, the upstream signaling network leading to the regulation of Pontin that in turn affects transcription of downstream target genes has not been extensively studied. Here, we identify Pontin is methylated by G9a/GLP methyltransferases in hypoxic condition and potentiates HIF-1 alpha-mediated activation by increasing the recruitment of p300 coactivator to a subset of HIF-1 alpha target promoters. Intriguingly, Pontin methylation results in the increased invasive and migratory properties by activating downstream target gene, Ets1. In contrast, inhibition of Pontin methylation results in the suppression of tumorigenic and metastatic properties. Together, our data provide new approaches by targeting Pontin methylation and its downstream targets for the development of therapeutic agents for human cancers. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Hypoxia-induced methylation of a pontin chromatin remodeling factor | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | en_US |
dc.identifier.doi | 10.1073/PNAS.1106106108 | - |
dc.author.google | Lee, JS | en_US |
dc.author.google | Kim, Y | en_US |
dc.author.google | Baek, SH | en_US |
dc.author.google | Hwang, D | en_US |
dc.author.google | Gozani, O | en_US |
dc.author.google | Binda, O | en_US |
dc.author.google | Yoon, JB | en_US |
dc.author.google | Lee, SH | en_US |
dc.author.google | Nam, HJ | en_US |
dc.author.google | Shin, HJR | en_US |
dc.author.google | Bhin, J | en_US |
dc.relation.volume | 108 | en_US |
dc.relation.issue | 33 | en_US |
dc.relation.startpage | 13510 | en_US |
dc.relation.lastpage | 13515 | en_US |
dc.contributor.id | 10180943 | en_US |
dc.relation.journal | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.108, no.33, pp.13510 - 13515 | - |
dc.identifier.wosid | 000293895100036 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 13515 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 13510 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 108 | - |
dc.contributor.affiliatedAuthor | Hwang, D | - |
dc.identifier.scopusid | 2-s2.0-80051978418 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 43 | - |
dc.description.scptc | 44 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | SIRTUIN 1 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | METHYLTRANSFERASE | - |
dc.subject.keywordPlus | SUMOYLATION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordAuthor | epigenetics | - |
dc.subject.keywordAuthor | transcriptional regulation | - |
dc.subject.keywordAuthor | covalent nonhistone modification | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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