DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, H | - |
dc.contributor.author | Banasr, M | - |
dc.contributor.author | Choi, M | - |
dc.contributor.author | Chae, SY | - |
dc.contributor.author | Licznerski, P | - |
dc.contributor.author | Lee, B | - |
dc.contributor.author | Voleti, B | - |
dc.contributor.author | Li, NX | - |
dc.contributor.author | Lepack, A | - |
dc.contributor.author | Fournier, NM | - |
dc.contributor.author | Lee, KR | - |
dc.contributor.author | Lee, IY | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Jung, SJ | - |
dc.contributor.author | Duman, RS | - |
dc.date.accessioned | 2015-06-25T03:28:22Z | - |
dc.date.available | 2015-06-25T03:28:22Z | - |
dc.date.created | 2012-08-01 | - |
dc.date.issued | 2012-07-10 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.other | 2015-OAK-0000025669 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/12765 | - |
dc.description.abstract | Decreased neuronal dendrite branching and plasticity of the hippocampus, a limbic structure implicated in mood disorders, is thought to contribute to the symptoms of depression. However, the mechanisms underlying this effect, as well as the actions of antidepressant treatment, remain poorly characterized. Here, we show that hippocampal expression of neuritin, an activity-dependent gene that regulates neuronal plasticity, is decreased by chronic unpredictable stress (CUS) and that antidepressant treatment reverses this effect. We also show that viral-mediated expression of neuritin in the hippocampus produces antidepressant actions and prevents the atrophy of dendrites and spines, as well as depressive and anxiety behaviors caused by CUS. Conversely, neuritin knockdown produces depressive-like behaviors, similar to CUS exposure. The ability of neuritin to increase neuroplasticity is confirmed in models of learning and memory. Our results reveal a unique action of neuritin in models of stress and depression, and demonstrate a role for neuroplasticity in antidepressant treatment response and related behaviors. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | NAS | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1073/pnas.1201191109 | - |
dc.author.google | Son, H | en_US |
dc.author.google | Banasr, M | en_US |
dc.author.google | Duman, RS | en_US |
dc.author.google | Jung, SJ | en_US |
dc.author.google | Kim, YH | en_US |
dc.author.google | Kim, JH | en_US |
dc.author.google | Kim, J | en_US |
dc.author.google | Lee, IY | en_US |
dc.author.google | Lee, KR | en_US |
dc.author.google | Fournier, NM | en_US |
dc.author.google | Lepack, A | en_US |
dc.author.google | Li, NX | en_US |
dc.author.google | Voleti, B | en_US |
dc.author.google | Lee, B | en_US |
dc.author.google | Licznerski, P | en_US |
dc.author.google | Chae, SY | en_US |
dc.author.google | Choi, M | en_US |
dc.relation.volume | 109 | en_US |
dc.relation.issue | 28 | en_US |
dc.relation.startpage | 11378 | en_US |
dc.relation.lastpage | 11383 | en_US |
dc.contributor.id | 10114767 | en_US |
dc.relation.journal | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.109, no.28, pp.11378 - 11383 | - |
dc.identifier.wosid | 000306642100070 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 11383 | - |
dc.citation.number | 28 | - |
dc.citation.startPage | 11378 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 109 | - |
dc.contributor.affiliatedAuthor | Kim, JH | - |
dc.identifier.scopusid | 2-s2.0-84863978334 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 54 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | DRUG DISCOVERY | - |
dc.subject.keywordPlus | CPG15 | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CORTEX | - |
dc.subject.keywordPlus | NEUROPLASTICITY | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | despair | - |
dc.subject.keywordAuthor | anhedonia | - |
dc.subject.keywordAuthor | BDNF | - |
dc.subject.keywordAuthor | synaptogenesis | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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