DC Field | Value | Language |
---|---|---|
dc.contributor.author | Br | - |
dc.contributor.author | t, JR | - |
dc.contributor.author | Lee, E | - |
dc.contributor.author | Boursalian, GB | - |
dc.contributor.author | Ritter, T | - |
dc.date.accessioned | 2015-07-07T19:06:46Z | - |
dc.date.available | 2015-07-07T19:06:46Z | - |
dc.date.created | 2013-12-19 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.other | 2015-OAK-0000028482 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/13100 | - |
dc.description.abstract | Electrophilic fluorinating reagents derived from fluoride are desirable for the synthesis of F-18-labeled molecules for positron emission tomography (PET). Here, we study the mechanism by which a Pd(IV)complex captures fluoride and subsequently transfers it to nucleophiles. The intermediate Pd(IV)-F is formed with high rates even at the nano-to micromolar fluoride concentrations typical for radiosyntheses with F-18 due to fast formation of an outer-sphere complex between fluoride and Pd(IV). The subsequent fluorine transfer from the Pd(IV)-F complex is proposed to proceed through an unusual SET/fluoride transfer/SET mechanism. The findings detailed in this manuscript provide a theoretical foundation suitable for addressing a more general approach for electrophilic fluorination with high specific activity F-18 PET imaging. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | The Royal Society of Chemistry | - |
dc.relation.isPartOf | CHEMICAL SCIENCE | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.subject | TRANSITION-METAL-COMPLEXES | - |
dc.subject | C-H FLUORINATION | - |
dc.subject | CATALYZED ALLYLIC FLUORINATION | - |
dc.subject | NUCLEAR MAGNETIC-RESONANCE | - |
dc.subject | LATE-STAGE FLUORINATION | - |
dc.subject | RADICAL CATIONS | - |
dc.subject | REDUCTIVE ELIMINATION | - |
dc.subject | STILBENE DERIVATIVES | - |
dc.subject | XENON DIFLUORIDE | - |
dc.subject | NUCLEOPHILIC FLUORINATION | - |
dc.title | Mechanism of electrophilic fluorination with Pd(IV): fluoride capture and subsequent oxidative fluoride transfer | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | en_US |
dc.identifier.doi | 10.1039/C3SC52367E | - |
dc.author.google | Brandt J.R., Lee E., Boursalian G.B., Ritter T. | en_US |
dc.relation.volume | 5 | en_US |
dc.relation.issue | 1 | en_US |
dc.relation.startpage | 169 | en_US |
dc.relation.lastpage | 179 | en_US |
dc.contributor.id | 10145005 | en_US |
dc.relation.journal | CHEMICAL SCIENCE | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CHEMICAL SCIENCE, v.5, no.1, pp.169 - 179 | - |
dc.identifier.wosid | 000327601600020 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 179 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 169 | - |
dc.citation.title | CHEMICAL SCIENCE | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | t, JR | - |
dc.identifier.scopusid | 2-s2.0-84888584215 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 28 | - |
dc.description.scptc | 28 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TRANSITION-METAL-COMPLEXES | - |
dc.subject.keywordPlus | C-H FLUORINATION | - |
dc.subject.keywordPlus | CATALYZED ALLYLIC FLUORINATION | - |
dc.subject.keywordPlus | REDUCTIVE ELIMINATION | - |
dc.subject.keywordPlus | RADICAL CATIONS | - |
dc.subject.keywordPlus | MEDIATED FLUORINATION | - |
dc.subject.keywordPlus | CHEMICAL-EXCHANGE | - |
dc.subject.keywordPlus | ION | - |
dc.subject.keywordPlus | SELECTFLUOR | - |
dc.subject.keywordPlus | F-18 | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
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