DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, SJ | - |
dc.contributor.author | Jeong, J | - |
dc.contributor.author | Park, YU | - |
dc.contributor.author | Park, KS | - |
dc.contributor.author | Lee, H | - |
dc.contributor.author | Lee, N | - |
dc.contributor.author | Kim, SM | - |
dc.contributor.author | Kuroda, K | - |
dc.contributor.author | Nguyen, MD | - |
dc.contributor.author | Kaibuchi, K | - |
dc.contributor.author | Park, SK | - |
dc.date.accessioned | 2015-07-22T19:03:20Z | - |
dc.date.available | 2015-07-22T19:03:20Z | - |
dc.date.created | 2015-06-22 | - |
dc.date.issued | 2015-03-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | 2015-OAK-0000033102 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/13192 | - |
dc.description.abstract | Disrupted-in-schizophrenia-1 (DISC1) has emerged as a convincing susceptibility gene for multiple mental disorders, but its mechanistic link to the pathogenesis of schizophrenia related psychiatric conditions is yet to be further understood. Here, we showed that DISC1 localizes to the outer surface of the endoplasmic reticulum (ER). EXOC1, a subunit of the exocyst complex, interacted with DISC1 and affected its recruitment to inositol-1,4,5-trisphosphate receptor 1 (IP3R1). Notably, knockdown of DISC1 and EXOC1 elicited an exaggerated ER calcium response upon stimulation of IP3R agonists. Similar abnormal ER calcium responses were observed in hippocampal neurons from DISC1-deficient mutant mice. Moreover, perturbation of ER calcium dynamics upon DISC1 knockdown was effectively reversed by treatment with antipsychotic drugs, such as clozapine and haloperidol. These results collectively indicate that DISC1 is a regulatory factor in ER calcium dynamics, linking a perturbed intracellular calcium signaling and schizophrenia pathogenesis. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.subject | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS | - |
dc.subject | EXOCYST COMPLEX | - |
dc.subject | HIPPOCAMPAL-NEURONS | - |
dc.subject | SCHIZOPHRENIA | - |
dc.subject | CA2+ | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | RELEASE | - |
dc.subject | MITOCHONDRIA | - |
dc.subject | MOBILIZATION | - |
dc.subject | INTERACTS | - |
dc.title | Disrupted-in-schizophrenia-1 (DISC1) Regulates Endoplasmic Reticulum Calcium Dynamics | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1038/SREP08694 | - |
dc.author.google | Park, SJ | en_US |
dc.author.google | Jeong, J | en_US |
dc.author.google | Park, YU | en_US |
dc.author.google | Park, KS | en_US |
dc.author.google | Lee, H | en_US |
dc.author.google | Lee, N | en_US |
dc.author.google | Kim, SM | en_US |
dc.author.google | Kuroda, K | en_US |
dc.author.google | Nguyen, MD | en_US |
dc.author.google | Kaibuchi, K | en_US |
dc.author.google | Park, SK | en_US |
dc.relation.volume | 5 | en_US |
dc.contributor.id | 10149637 | en_US |
dc.relation.journal | SCIENTIFIC REPORTS | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCIE | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.5 | - |
dc.identifier.wosid | 000350350500015 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Park, SK | - |
dc.identifier.scopusid | 2-s2.0-84924020927 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 15 | - |
dc.description.scptc | 15 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS | - |
dc.subject.keywordPlus | EXOCYST COMPLEX | - |
dc.subject.keywordPlus | HIPPOCAMPAL-NEURONS | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | CA2+ | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | MOBILIZATION | - |
dc.subject.keywordPlus | INTERACTS | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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