DC Field | Value | Language |
---|---|---|
dc.contributor.author | Soh, YM | - |
dc.contributor.author | Burmann, F | - |
dc.contributor.author | Shin, HC | - |
dc.contributor.author | Oda, T | - |
dc.contributor.author | Jin, KS | - |
dc.contributor.author | C. P. Toseland | - |
dc.contributor.author | C. Kim | - |
dc.contributor.author | Kim, C | - |
dc.contributor.author | S. J. Kim | - |
dc.contributor.author | M-S Kong | - |
dc.contributor.author | M-L Durand-Diebold | - |
dc.contributor.author | Y.-G. Kim | - |
dc.contributor.author | -Diebold, ML | - |
dc.contributor.author | Kim, YG | - |
dc.contributor.author | Kim, HM | - |
dc.contributor.author | Lee, NK | - |
dc.contributor.author | S. Gruber | - |
dc.contributor.author | Oh, BH | - |
dc.contributor.author | Gruber, S | - |
dc.date.accessioned | 2016-03-31T07:23:27Z | - |
dc.date.available | 2016-03-31T07:23:27Z | - |
dc.date.created | 2015-02-26 | - |
dc.date.issued | 2015-01-22 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.other | 2015-OAK-0000032356 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/13580 | - |
dc.description.abstract | SMC condensin complexes are central modulators of chromosome superstructure in all branches of life. Their SMC subunits form a long intramolecular coiled coil, which connects a constitutive "hinge'' dimerization domain with an ATP-regulated "head'' dimerization module. Here, we address the structural arrangement of the long coiled coils in SMC complexes. We unequivocally show that prokaryotic Smc-ScpAB, eukaryotic condensin, and possibly also cohesin form rod-like structures, with their coiled coils being closely juxtaposed and accurately anchored to the hinge. Upon ATP-induced binding of DNA to the hinge, however, Smc switches to a more open configuration. Our data suggest that a long-distance structural transition is transmitted from the Smc head domains to regulate Smc-ScpAB's association with DNA. These findings uncover a conserved architectural theme in SMC complexes, provide a mechanistic basis for Smc's dynamic engagement with chromosomes, and offer a molecular explanation for defects in Cornelia de Lange syndrome. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | Molecular Cell | - |
dc.title | Molecular basis for SMC rod formation and its dissolution upon DNA binding | - |
dc.type | Article | - |
dc.contributor.college | 물리학과 | - |
dc.identifier.doi | 10.1016/J.MOLCEL.2014.11.023 | - |
dc.author.google | Soh, YM | - |
dc.author.google | Burmann, F | - |
dc.author.google | Shin, HC | - |
dc.author.google | Oda, T | - |
dc.author.google | Jin, KS | - |
dc.author.google | Toseland, CP | - |
dc.author.google | Kim, C | - |
dc.author.google | Lee, H | - |
dc.author.google | Kim, SJ | - |
dc.author.google | Kong, MS | - |
dc.author.google | Durand-Diebold, ML | - |
dc.author.google | Kim, YG | - |
dc.author.google | Kim, HM | - |
dc.author.google | Lee, NK | - |
dc.author.google | Sato, M | - |
dc.author.google | Oh, BH | - |
dc.author.google | Gruber, S Soh, Young-Min | - |
dc.author.google | Buermann, | - |
dc.relation.volume | 57 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 290 | - |
dc.relation.lastpage | 303 | - |
dc.contributor.id | 10206847 | - |
dc.relation.journal | MOLECULAR CELL | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Molecular Cell, v.57, no.2, pp.290 - 303 | - |
dc.identifier.wosid | 000348507800009 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 303 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 290 | - |
dc.citation.title | Molecular Cell | - |
dc.citation.volume | 57 | - |
dc.contributor.affiliatedAuthor | Kim, YG | - |
dc.identifier.scopusid | 2-s2.0-84921445757 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 52 | - |
dc.description.scptc | 43 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | X-RAY-SCATTERING | - |
dc.subject.keywordPlus | HINGE DOMAIN | - |
dc.subject.keywordPlus | CHROMOSOME CONDENSATION | - |
dc.subject.keywordPlus | FUNCTIONAL IMPLICATIONS | - |
dc.subject.keywordPlus | STRUCTURAL MAINTENANCE | - |
dc.subject.keywordPlus | BACILLUS-SUBTILIS | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | ATP HYDROLYSIS | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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