DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Y | - |
dc.contributor.author | Kumagai, Y | - |
dc.contributor.author | Jang, MS | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Yang, BG | - |
dc.contributor.author | Lee, EJ | - |
dc.contributor.author | Kim, YM | - |
dc.contributor.author | Akira, S | - |
dc.contributor.author | Jang, MH | - |
dc.date.accessioned | 2016-03-31T07:28:08Z | - |
dc.date.available | 2016-03-31T07:28:08Z | - |
dc.date.created | 2015-02-23 | - |
dc.date.issued | 2013-05-15 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2013-OAK-0000032117 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/13665 | - |
dc.description.abstract | Small intestinal innate lymphoid cells (ILCs) regulate intestinal epithelial cell homeostasis and help to prevent pathogenic bacterial infections by producing IL-22. In a global gene-expression analysis comparing small intestinal ILCs (Lin(-)c-Kit(+)Sca-1(-) cells) with non-ILCs (Lin(-)c-Kit(-)Sca-1(-) cells), we found that Lin(-)c-Kit(+)Sca-1(-) cells highly expressed the mRNAs for Il22, antimicrobial peptides, Csf2rb2 (Il3r), mast cell proteases, and Rorc. We then subdivided the Lin(-)c-Kit(+)Sca-1(-) cells into three groups-Lin(-)c-Kit(+)NKp46(-)CD4(-), Lin(-)c-Kit(+)NKp46(-)CD4(+) (CD4(+) LTi-like cells), and Lin(-)c-Kit(+)NKp46(+) (NKp46(+) ILC22 cells)-and showed that the Lin(-)c-Kit(+)NKp46(-)CD4(-) cells produced the highest level of IL-22 protein after IL-1 beta, IL-23, or IL-1 beta and IL-23 stimulation. In addition, we showed that the majority of the Lin(-)c-Kit(+)NKp46(-)CD4(-) population was IL-7R alpha(+)CD34(-)beta 7(int) cells, and IL-7R alpha(-) cells could be divided into three subsets (CD34(+)beta 7(int), CD34(-)beta 7(int), and CD34(int)beta 7(hi) cells). The IL-7R alpha(+)CD34(-)beta 7(int) cells strongly expressed the transcripts for Il17f and Il22 after costimulation with IL-1 beta and IL-23. The IL-7R alpha(-)CD34(+)beta 7(int) and IL-7R alpha(-)CD34(int)beta 7(hi) cells predominantly expressed the transcripts for mast cell proteases and differentiated almost entirely into mast cells after 1 wk in culture medium supplemented with a cytokine mixture, whereas the IL-7R alpha(-)CD34(+)beta 7(int) cells highly expressed alpha-defensins and showed no differentiation. Taken together, these findings indicate that the IL-7R alpha(-)CD34(+)beta 7(int) and IL-7R alpha(-)CD34(int)beta 7(hi) populations are mast cell progenitors, and the IL-7R alpha(-)CD34(-)beta 7(int) (CD4(-) LTi-like cells) and IL-7R alpha(-)CD34(-)beta 7(int) populations within Lin(-)c-Kit(+)NKp46(-)CD4(-) cells may control intestinal homeostasis and provide intestinal protection by producing high levels of IL-22 and alpha-defensins, respectively. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | INNATE LYMPHOID-CELLS | - |
dc.subject | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject | MAST-CELLS | - |
dc.subject | ANTIMICROBIAL PEPTIDES | - |
dc.subject | ALPHA-DEFENSINS | - |
dc.subject | HOST-DEFENSE | - |
dc.subject | BONE-MARROW | - |
dc.subject | TRICHINELLA-SPIRALIS | - |
dc.subject | BARRIER FUNCTION | - |
dc.subject | DENDRITIC CELLS | - |
dc.title | Intestinal Lin(-)c-Kit(+)NKp46(-)CD4(-) Population Strongly Produces IL-22 upon IL-1 beta Stimulation | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.4049/JIMMUNOL.1201452 | - |
dc.author.google | Lee, Y | - |
dc.author.google | Kumagai, Y | - |
dc.author.google | Jang, MS | - |
dc.author.google | Kim, JH | - |
dc.author.google | Yang, BG | - |
dc.author.google | Lee, EJ | - |
dc.author.google | Kim, YM | - |
dc.author.google | Akira, S | - |
dc.author.google | Jang, MH | - |
dc.relation.volume | 190 | - |
dc.relation.issue | 10 | - |
dc.relation.startpage | 5296 | - |
dc.relation.lastpage | 5305 | - |
dc.contributor.id | 10608366 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.190, no.10, pp.5296 - 5305 | - |
dc.identifier.wosid | 000318546700041 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 5305 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 5296 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 190 | - |
dc.contributor.affiliatedAuthor | Kim, YM | - |
dc.identifier.scopusid | 2-s2.0-84877799485 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 11 | - |
dc.description.scptc | 12 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INNATE LYMPHOID-CELLS | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | ANTIMICROBIAL PEPTIDES | - |
dc.subject.keywordPlus | ALPHA-DEFENSINS | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | TRICHINELLA-SPIRALIS | - |
dc.subject.keywordPlus | BARRIER FUNCTION | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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