DC Field | Value | Language |
---|---|---|
dc.contributor.author | Humphreys, IR | - |
dc.contributor.author | Lee, SW | - |
dc.contributor.author | Jones, M | - |
dc.contributor.author | Loewendorf, A | - |
dc.contributor.author | Gostick, E | - |
dc.contributor.author | Price, DA | - |
dc.contributor.author | Benedict, CA | - |
dc.contributor.author | Ware, CF | - |
dc.contributor.author | Croft, M | - |
dc.date.accessioned | 2016-03-31T07:56:16Z | - |
dc.date.available | 2016-03-31T07:56:16Z | - |
dc.date.created | 2015-02-03 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.other | 2010-OAK-0000030863 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14200 | - |
dc.description.abstract | The initial requirement for the emergence of CMV-specific CD8(+) T cells is poorly understood. Mice deficient in the cosignaling TNF superfamily member, 4-1BB, surprisingly developed exaggerated early CD8(+) T-cell responses to mouse CMV (MCMV). CD8(+) T cells directed against acute MCMV epitopes were enhanced, demonstrating that 4-1BB naturally antagonizes these primary populations. Paradoxically, 4-1BB-deficient mice displayed reduced accumulation of memory CD8+ T cells that expand during chronic/latent infection. Importantly, the canonical TNF-related ligand, 4-1BBL, promoted the accumulation of these memory CD8+ T cells, whereas suppression of acute CD8(+) T cells was independent of 4-1BBL. These data highlight the dual nature of the 4-1BB/4-1BBL system in mediating both stimulatory and inhibitory cosignaling activities during the generation of anti-MCMV immunity. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | European Journal of Immunology | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.subject | 4-1BB | - |
dc.subject | CD8(+) T cells | - |
dc.subject | CMV | - |
dc.subject | Memory | - |
dc.subject | ALLOGENEIC BONE-MARROW | - |
dc.subject | MURINE CYTOMEGALOVIRUS | - |
dc.subject | MEMORY INFLATION | - |
dc.subject | VIRAL-INFECTION | - |
dc.subject | IN-VIVO | - |
dc.subject | RESPONSES | - |
dc.subject | COSTIMULATION | - |
dc.subject | LIGAND | - |
dc.subject | IMMUNITY | - |
dc.subject | OX40 | - |
dc.title | Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8 T cells | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1002/EJI.200940256 | - |
dc.author.google | Humphreys, IR | - |
dc.author.google | Lee, SW | - |
dc.author.google | Jones, M | - |
dc.author.google | Loewendorf, A | - |
dc.author.google | Gostick, E | - |
dc.author.google | Price, DA | - |
dc.author.google | Benedict, CA | - |
dc.author.google | Ware, CF | - |
dc.author.google | Croft, M | - |
dc.relation.volume | 40 | - |
dc.relation.issue | 10 | - |
dc.relation.startpage | 2762 | - |
dc.relation.lastpage | 2768 | - |
dc.contributor.id | 10113012 | - |
dc.relation.journal | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF IMMUNOLOGY, v.40, no.10, pp.2762 - 2768 | - |
dc.identifier.wosid | 000283387500014 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 2768 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2762 | - |
dc.citation.title | EUROPEAN JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 40 | - |
dc.contributor.affiliatedAuthor | Lee, SW | - |
dc.identifier.scopusid | 2-s2.0-77957102912 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 38 | - |
dc.description.scptc | 33 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ALLOGENEIC BONE-MARROW | - |
dc.subject.keywordPlus | MURINE CYTOMEGALOVIRUS | - |
dc.subject.keywordPlus | MEMORY INFLATION | - |
dc.subject.keywordPlus | VIRAL-INFECTION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | COSTIMULATION | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | OX40 | - |
dc.subject.keywordAuthor | 4-1BB | - |
dc.subject.keywordAuthor | CD8(+) T cells | - |
dc.subject.keywordAuthor | CMV | - |
dc.subject.keywordAuthor | Memory | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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