DC Field | Value | Language |
---|---|---|
dc.contributor.author | Eun, SY | - |
dc.contributor.author | Lee, SW | - |
dc.contributor.author | Xu, YF | - |
dc.contributor.author | Croft, M | - |
dc.date.accessioned | 2016-03-31T07:57:00Z | - |
dc.date.available | 2016-03-31T07:57:00Z | - |
dc.date.created | 2015-02-02 | - |
dc.date.issued | 2015-01-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2015-OAK-0000030819 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14227 | - |
dc.description.abstract | 4-1BB ligand (4-1BBL) and its receptor, 4-1BB, are both induced on T cells after activation, but little is known about the role of 4-1BBL. In this study we show that 4-1BBL can transmit signals that limit T cell effector activity under tolerogenic conditions. Cross-linking 4-1BBL inhibited IL-2 production in vitro, primarily with suboptimal TCR stimulation. Furthermore, naive 4-1BBL-deficient OT-II transgenic T cells displayed a greater conversion to effector T cells in vivo when responding to soluble OVA peptide in wild-type hosts, whereas development of Foxp3(+) regulatory T cells was not altered. A greater number of effector T cells also differentiated from naive wild-type OT-II T cells when transferred into 4-1BB-deficient hosts, suggesting that APC-derived 4-1BB is likely to trigger 4-1BBL. Indeed, effector T cells that could not express 4-1BBL accumulated in larger numbers in vitro when stimulated with 4-1BB-expressing mesenteric lymph node dendritic cells. 4-1BBL was expressed on T cells when Ag presentation was limiting, and 4-1BBL was aberrantly expressed at very high levels on T cells that could not express 4-1BB. Trans-ligation, Ab capture, and endocytosis experiments additionally showed that T cell-intrinsic 4-1BB regulated internalization of membrane 4-1BBL, implying that the strong induction of 4-1BB on T cells may counteract the suppressive function of 4-1BBL by limiting its availability. These data suggest that 4-1BBL expressed on T cells can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues where 4-1BB-expressing regulatory dendritic cells present Ag. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | American Association of Immunologists | - |
dc.relation.isPartOf | Journal of Immunology | - |
dc.title | 4-1BB Ligand Signaling to T Cells Limits T Cell Activation | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.4049/JIMMUNOL.1401383 | - |
dc.author.google | Eun, SY | - |
dc.author.google | Lee, SW | - |
dc.author.google | Xu, YF | - |
dc.author.google | Croft, M | - |
dc.relation.volume | 194 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 134 | - |
dc.relation.lastpage | 141 | - |
dc.contributor.id | 10113012 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Journal of Immunology, v.194, no.1, pp.134 - 141 | - |
dc.identifier.wosid | 000346700500016 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 141 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 134 | - |
dc.citation.title | Journal of Immunology | - |
dc.citation.volume | 194 | - |
dc.contributor.affiliatedAuthor | Lee, SW | - |
dc.identifier.scopusid | 2-s2.0-84919608883 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 14 | - |
dc.description.scptc | 9 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | CD137 LIGAND | - |
dc.subject.keywordPlus | LYMPHOCYTE PROLIFERATION | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | TNF SUPERFAMILY | - |
dc.subject.keywordPlus | RECEPTOR FAMILY | - |
dc.subject.keywordPlus | OSTEOCLASTOGENESIS | - |
dc.subject.keywordPlus | MEMBER | - |
dc.subject.keywordPlus | MICE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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