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Cited 78 time in webofscience Cited 83 time in scopus
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dc.contributor.authorShim, JH-
dc.contributor.authorKim, SE-
dc.contributor.authorPark, JY-
dc.contributor.authorKundu, J-
dc.contributor.authorKim, SW-
dc.contributor.authorKang, SS-
dc.contributor.authorCho, DW-
dc.date.accessioned2016-03-31T07:57:28Z-
dc.date.available2016-03-31T07:57:28Z-
dc.date.created2015-01-20-
dc.date.issued2014-07-
dc.identifier.issn1937-3341-
dc.identifier.other2014-OAK-0000030747-
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/14244-
dc.description.abstractIn this study, recombinant human bone morphogenetic protein-2 (rhBMP-2) delivery system with slow mode was successfully developed in three-dimensional (3D) printing-based polycaprolactone (PCL)/poly(lactic-co-glycolic acid) (PLGA) scaffolds for bone formation of critical-sized rabbit segmental diaphyseal defect. To control the delivery of the rhBMP-2, collagen (for long-term delivery up to 28 days) and gelatin (for shor-term delivery within a week) solutions encapsulating rhBMP-2 were dispensed into a hollow cylinderical type of PCL/PLGA scaffold. An effective dose of 5mg/mL was determined by measuring the alkaline phosphatase and osteocalcin gene expression levels of human nasal inferior turbinate-derived mesenchymal stromal cells (hTMSCs) seeded on the PCL/PLGA/collagen scaffold in vitro. However, it was found that a burst release of rhBMP-2 from the PCL/PLGA/gelatin scaffold did not induce the osteogenic differentiation of hTMSCs in vitro at an equivalent dose. In the in vivo animal experiements, microcomputed tomography and histological analyses confirmed that PCL/PLGA/collagen/rhBMP-2 scaffolds (long-term delivery mode) showed the best bone healing quality at both weeks 4 and 8 after implantation without inflammatory response. On the other hand, a large number of macrophages indicating severe inflammation provoked by burst release of rhBMP-2 were observed in the vicinity of PCL/PLGA/gelatin/rhBMP-2 (short-term delivery mode) at week 4.-
dc.description.statementofresponsibilityX-
dc.languageEnglish-
dc.publisher"MARY ANN LIEBERT, INC"-
dc.relation.isPartOfTISSUE ENGINEERING PART A-
dc.subjectMESENCHYMAL STROMAL CELLS-
dc.subjectMORPHOGENETIC PROTEIN-2 USE-
dc.subjectHEAD DEPOSITION SYSTEM-
dc.subjectFREE-FORM FABRICATION-
dc.subjectOSTEOGENIC DIFFERENTIATION-
dc.subjectINFLAMMATORY RESPONSE-
dc.subjectILIAC CREST-
dc.subjectIN-VIVO-
dc.subjectSTRATEGIES-
dc.subjectTURBINATE-
dc.titleThree-Dimensional Printing of rhBMP-2-Loaded Scaffolds with Long-Term Delivery for Enhanced Bone Regeneration in a Rabbit Diaphyseal Defect-
dc.typeArticle-
dc.contributor.college기계공학과-
dc.identifier.doi10.1089/TEN.TEA.2013.0513-
dc.author.googleShim, JH-
dc.author.googleKim, SE-
dc.author.googlePark, JY-
dc.author.googleKundu, J-
dc.author.googleKim, SW-
dc.author.googleKang, SS-
dc.author.googleCho, DW-
dc.relation.volume20-
dc.relation.issue13-14-
dc.relation.startpage1980-
dc.relation.lastpage1992-
dc.contributor.id10102903-
dc.relation.journalTISSUE ENGINEERING PART A-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.relation.sciSCI-
dc.collections.nameJournal Papers-
dc.type.rimsART-
dc.identifier.bibliographicCitationTISSUE ENGINEERING PART A, v.20, no.13-14, pp.1980 - 1992-
dc.identifier.wosid000339171900020-
dc.date.tcdate2019-01-01-
dc.citation.endPage1992-
dc.citation.number13-14-
dc.citation.startPage1980-
dc.citation.titleTISSUE ENGINEERING PART A-
dc.citation.volume20-
dc.contributor.affiliatedAuthorCho, DW-
dc.identifier.scopusid2-s2.0-84904211382-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc36-
dc.description.scptc31*
dc.date.scptcdate2018-05-121*
dc.type.docTypeArticle-
dc.subject.keywordPlusMORPHOGENETIC PROTEIN-2 USE-
dc.subject.keywordPlusMESENCHYMAL STROMAL CELLS-
dc.subject.keywordPlusFREE-FORM FABRICATION-
dc.subject.keywordPlusOSTEOGENIC DIFFERENTIATION-
dc.subject.keywordPlusINFLAMMATORY RESPONSE-
dc.subject.keywordPlusSTRATEGIES-
dc.subject.keywordPlusTURBINATE-
dc.subject.keywordPlusBMP-2-
dc.subject.keywordPlusDEGRADATION-
dc.subject.keywordPlusCOMBINATION-
dc.relation.journalWebOfScienceCategoryCell & Tissue Engineering-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalResearchAreaMaterials Science-

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조동우CHO, DONG WOO
Dept of Mechanical Enginrg
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