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Effects of alginate hydrogel cross-linking density on mechanical and biological behaviors for tissue engineering SCIE SCOPUS

Title
Effects of alginate hydrogel cross-linking density on mechanical and biological behaviors for tissue engineering
Authors
Jang, JSeol, YJKim, HJKundu, JKim, SWCho, DW
Date Issued
2014-09
Publisher
ELSEVIER SCIENCE BV
Abstract
An effective cross-linking of alginate gel was made through reaction with calcium carbonate (CaCO3). We used human chondrocytes as a model cell to study the effects of cross-linking density. Three different pore size ranges of cross-linked alginate hydrogels were fabricated. The morphological, mechanical, and rheological properties of various alginate hydrogels were characterized and responses of biosynthesis of cells encapsulated in each gel to the variation in cross-linking density were investigated. Desired outer shape of structure was maintained when the alginate solution was cross-linked with the applied method. The properties of alginate hydrogel could be tailored through applying various concentrations of CaCO3. The rate of synthesized GAGs and collagens was significantly higher in human chondrocytes encapsulated in the smaller pore structure than that in the larger pore structure. The expression of chondrogenic markers, including collagen type II and aggrecan, was enhanced in the smaller pore structure. It was found that proper structural morphology is a critical factor to enhance the performance and tissue regeneration. (C) 2014 Elsevier Ltd. All rights reserved.
Keywords
Alginate; Tissue engineering; Hydrogel; Structure-properties relations; Cross-linking; PORE-SIZE; IN-VITRO; ARTICULAR-CARTILAGE; CHONDROGENIC DIFFERENTIATION; CHONDROCYTE CONSTRUCTS; OXYGEN-TENSION; CELL-DENSITY; STEM-CELLS; SCAFFOLDS; MATRIX
URI
https://oasis.postech.ac.kr/handle/2014.oak/14245
DOI
10.1016/J.JMBBM.2014.05.004
ISSN
1751-6161
Article Type
Article
Citation
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, vol. 37, page. 69 - 77, 2014-09
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조동우CHO, DONG WOO
Dept of Mechanical Enginrg
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