Aptamer-conjugated magnetic nanoparticles enable efficient targeted detection of integrin alpha v beta 3 via magnetic resonance imaging

Abstract

An understanding of neovascularization and/or angiogenesis in cancer is acutely required for effective cancer therapy due to concerns about tumor growth and metastasis. In particular, integrin v3 is closely associated with cell migration and invasion during angiogenesis. Hence, we developed aptamer(v3)-conjugated magnetic nanoparticles (Apt(v3)-MNPs) to enable precise detection of integrin-expressing cancer cells using magnetic resonance imaging. Apt(v3)-MNPs exhibited not only cytocompatibility, but also an efficient targeting ability with high magnetic sensitivity through in vitro/in vivo studies. The results of this study demonstrate that Apt(v3)-MNPs have the potential to be used for accurate tumor diagnosis and therapy. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 49-59, 2014.