DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koh, A | - |
dc.contributor.author | Park, D | - |
dc.contributor.author | Jeong, H | - |
dc.contributor.author | Lee, J | - |
dc.contributor.author | Lee, MN | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Ryu, SH | - |
dc.date.accessioned | 2016-03-31T07:57:47Z | - |
dc.date.available | 2016-03-31T07:57:47Z | - |
dc.date.created | 2015-01-20 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 0898-6568 | - |
dc.identifier.other | 2014-OAK-0000030721 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14256 | - |
dc.description.abstract | C1-Ten is a member of the tensin family of focal adhesion molecules but recent studies suggest it plays a more active role in many biological processes because of its potential association with diabetes and cancers. However, relatively little is known about the regulation of C1-Ten, such as changes in its protein level or cellular localization. The cellular localization of C1-Ten is Unique because it is expressed in cytoplasmic puncta but nothing is known about these puncta. Here, we show that p62 sequestrates C1-Ten into puncta, making C1-Ten diffuse into the cytoplasm upon p62 depletion. More importantly, p62-mediated C1-Ten sequestration promoted C1-Ten ubiquitination and proteasomal degradation. p62-mediated protein reduction was specific to C1-Ten, and not other tensins such as tensin1 and tensin3. Thus, our results link cellular localization of C1-Ten to an off-switch site for C1-Ten. Additionally, p62 expression increased but C1-Ten protein decreased during muscle differentiation, supporting a role for p62 as, a physiological regulator of C1-Ten. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELLULAR SIGNALLING | - |
dc.relation.isPartOf | CELLULAR SIGNALLING | - |
dc.subject | C1-Ten | - |
dc.subject | Tensin2 | - |
dc.subject | p62 | - |
dc.subject | Sequestosome | - |
dc.subject | Degradation | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | CELL-MIGRATION | - |
dc.subject | NEGATIVE REGULATOR | - |
dc.subject | SEQUESTOSOME 1/P62 | - |
dc.subject | SH2 DOMAIN | - |
dc.subject | CANCER | - |
dc.subject | P62 | - |
dc.subject | AUTOPHAGY | - |
dc.subject | UBIQUITIN | - |
dc.subject | BINDING | - |
dc.title | Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.CELLSIG.2014.07.033 | - |
dc.author.google | Koh, A | - |
dc.author.google | Park, D | - |
dc.author.google | Jeong, H | - |
dc.author.google | Lee, J | - |
dc.author.google | Lee, MN | - |
dc.author.google | Suh, PG | - |
dc.author.google | Ryu, SH | - |
dc.relation.volume | 26 | - |
dc.relation.issue | 11 | - |
dc.relation.startpage | 2470 | - |
dc.relation.lastpage | 2480 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | CELLULAR SIGNALLING | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CELLULAR SIGNALLING, v.26, no.11, pp.2470 - 2480 | - |
dc.identifier.wosid | 000342717400019 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 2480 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2470 | - |
dc.citation.title | CELLULAR SIGNALLING | - |
dc.citation.volume | 26 | - |
dc.contributor.affiliatedAuthor | Jeong, H | - |
dc.contributor.affiliatedAuthor | Lee, J | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-84906061893 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 2 | - |
dc.description.scptc | 1 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | CELL-MIGRATION | - |
dc.subject.keywordPlus | NEGATIVE REGULATOR | - |
dc.subject.keywordPlus | SEQUESTOSOME 1/P62 | - |
dc.subject.keywordPlus | SH2 DOMAIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | P62 | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | UBIQUITIN | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordAuthor | C1-Ten | - |
dc.subject.keywordAuthor | Tensin2 | - |
dc.subject.keywordAuthor | p62 | - |
dc.subject.keywordAuthor | Sequestosome | - |
dc.subject.keywordAuthor | Degradation | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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