DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ren Sheng | - |
dc.contributor.author | Hyunjoon Kim | - |
dc.contributor.author | Hyeyoon Lee | - |
dc.contributor.author | Yao Xin | - |
dc.contributor.author | Yong Chen | - |
dc.contributor.author | Wen Tian | - |
dc.contributor.author | Yang Cui | - |
dc.contributor.author | Jong-Cheol Choi | - |
dc.contributor.author | Doh, J | - |
dc.contributor.author | Han, JK | - |
dc.contributor.author | Wonhwa Cho | - |
dc.date.accessioned | 2016-03-31T08:02:55Z | - |
dc.date.available | 2016-03-31T08:02:55Z | - |
dc.date.created | 2014-07-30 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.other | 2014-OAK-0000030143 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14442 | - |
dc.description.abstract | Wnt proteins control diverse biological processes through beta-catenin-dependent canonical signalling and beta-catenin-independent non-canonical signalling. The mechanisms by which these signalling pathways are differentially triggered and controlled are not fully understood. Dishevelled (Dvl) is a scaffold protein that serves as the branch point of these pathways. Here, we show that cholesterol selectively activates canonical Wnt signalling over non-canonical signalling under physiological conditions by specifically facilitating the membrane recruitment of the PDZ domain of Dvl and its interaction with other proteins. Single-molecule imaging analysis shows that cholesterol is enriched around the Wnt-activated Frizzled and low-density lipoprotein receptor-related protein 5/6 receptors and plays an essential role for Dvl-mediated formation and maintenance of the canonical Wnt signalling complex. Collectively, our results suggest a new regulatory role of cholesterol in Wnt signalling and a potential link between cellular cholesterol levels and the balance between canonical and non-canonical Wnt signalling activities. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Nature communications | - |
dc.relation.isPartOf | Nature communications | - |
dc.subject | CONVERGENT EXTENSION MOVEMENTS | - |
dc.subject | DISHEVELLED DEP DOMAIN | - |
dc.subject | PLASMA-MEMBRANE | - |
dc.subject | BETA-CATENIN | - |
dc.subject | PDZ DOMAIN | - |
dc.subject | PROTEIN INTERACTIONS | - |
dc.subject | CELL POLARITY | - |
dc.subject | BINDING | - |
dc.subject | PATHWAY | - |
dc.subject | INHIBITION | - |
dc.title | Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling | - |
dc.type | Article | - |
dc.contributor.college | 기계공학과 | - |
dc.identifier.doi | 10.1038/NCOMMS5393 | - |
dc.author.google | Sheng R., Kim H., Lee H., Xin Y., Chen Y., Tian W., Cui Y., Choi J.-C., Doh J., Han J.-K., Cho W. | - |
dc.relation.volume | 5 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 4393 | - |
dc.relation.lastpage | 4406 | - |
dc.contributor.id | 10189091 | - |
dc.relation.journal | Nature communications | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Nature communications, v.5, no.1, pp.4393 - 4406 | - |
dc.identifier.wosid | 000340618700008 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 4406 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 4393 | - |
dc.citation.title | Nature communications | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Doh, J | - |
dc.contributor.affiliatedAuthor | Han, JK | - |
dc.identifier.scopusid | 2-s2.0-84904489367 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 19 | - |
dc.description.scptc | 15 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DISHEVELLED DEP DOMAIN | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | PDZ DOMAIN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | LRP6 | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | REQUIRES | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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