Palladium-catalyzed C-H functionalization of pyridine-N-oxides: Highly selective alkenylation and direct arylation with unactivated arenes
SCIE
SCOPUS
- Title
- Palladium-catalyzed C-H functionalization of pyridine-N-oxides: Highly selective alkenylation and direct arylation with unactivated arenes
- Authors
- Cho, SH; HWANG, SEUNG JUN; Chang, S
- Date Issued
- 2008-07-23
- Publisher
- American Chemical Society
- Abstract
- Two catalytic protocols of the oxidative C-C bond formation have been developed on the basis of the C-H bond activation of pyyidine N-oxides Pd-catalyzed alkenylation of the N-oxides proceeds with excellent regio-, stereo-, and chemoselectivity, and the corresponding ortho-alkenylated N-oxide derivatives are obtained in good to excellent yields, Direct cross-coupling reaction of pyridine N-oxides with unactivated arene was also developed in the presence of Pd catalyst and Ag oxidant, which affords ortho-arylated pyridine N-oxide products with high site-selectivity.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/14443
- DOI
- 10.1021/JA8026295
- ISSN
- 0002-7863
- Article Type
- Article
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 29, page. 9254 - 9256, 2008-07-23
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