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Cited 7 time in webofscience Cited 9 time in scopus
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dc.contributor.authorChoi, YS-
dc.contributor.authorYoon, S-
dc.contributor.authorKim, KL-
dc.contributor.authorYoo, J-
dc.contributor.authorSong, P-
dc.contributor.authorKim, M-
dc.contributor.authorShin, YE-
dc.contributor.authorYang, WJ-
dc.contributor.authorNoh, JE-
dc.contributor.authorCho, HS-
dc.contributor.authorKim, S-
dc.contributor.authorChung, J-
dc.contributor.authorRyu, SH-
dc.date.accessioned2016-03-31T08:03:51Z-
dc.date.available2016-03-31T08:03:51Z-
dc.date.created2015-01-20-
dc.date.issued2014-04-07-
dc.identifier.issn1932-6203-
dc.identifier.other2014-OAK-0000030024-
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/14478-
dc.description.abstractWe developed a process to produce novel interactions between two previously unrelated proteins. This process selects protein scaffolds and designs protein interfaces that bind to a surface patch of interest on a target protein. Scaffolds with shapes complementary to the target surface patch were screened using an exhaustive computational search of the human proteome and optimized by directed evolution using phage display. This method was applied to successfully design scaffolds that bind to epidermal growth factor receptor (EGFR) domain II, the interface of EGFR dimerization, with high reactivity toward the target surface patch of EGFR domain II. One potential application of these tailor-made protein interactions is the development of therapeutic agents against specific protein targets.-
dc.description.statementofresponsibilityX-
dc.languageEnglish-
dc.publisherPLOS ONE-
dc.relation.isPartOfPLOS ONE-
dc.titleComputational Design of Binding Proteins to EGFR Domain II-
dc.typeArticle-
dc.contributor.college생명과학과-
dc.identifier.doi10.1371/JOURNAL.PONE.0092513-
dc.author.googleChoi, YS-
dc.author.googleYoon, S-
dc.author.googleKim, KL-
dc.author.googleYoo, J-
dc.author.googleSong, P-
dc.author.googleKim, M-
dc.author.googleShin, YE-
dc.author.googleYang, WJ-
dc.author.googleNoh, JE-
dc.author.googleCho, HS-
dc.author.googleKim, S-
dc.author.googleChung, J-
dc.author.googleRyu, SH-
dc.relation.volume9-
dc.relation.issue4-
dc.contributor.id10136479-
dc.relation.journalPLOS ONE-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.relation.sciSCI-
dc.collections.nameJournal Papers-
dc.type.rimsART-
dc.identifier.bibliographicCitationPLOS ONE, v.9, no.4-
dc.identifier.wosid000334159800013-
dc.date.tcdate2019-01-01-
dc.citation.number4-
dc.citation.titlePLOS ONE-
dc.citation.volume9-
dc.contributor.affiliatedAuthorNoh, JE-
dc.contributor.affiliatedAuthorKim, S-
dc.contributor.affiliatedAuthorRyu, SH-
dc.identifier.scopusid2-s2.0-84899419835-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc4-
dc.description.scptc6*
dc.date.scptcdate2018-05-121*
dc.type.docTypeArticle-
dc.subject.keywordPlusEPIDERMAL-GROWTH-FACTOR-
dc.subject.keywordPlusDATA-BANK-
dc.subject.keywordPlusEVOLUTIONARY CONSERVATION-
dc.subject.keywordPlusTRANSMEMBRANE PROTEINS-
dc.subject.keywordPlusINTERACTION NETWORKS-
dc.subject.keywordPlusFACTOR RECEPTOR-
dc.subject.keywordPlusCANCER-THERAPY-
dc.subject.keywordPlusPHASE-I-
dc.subject.keywordPlusCOMPLEX-
dc.subject.keywordPlusANTICALINS-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-

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김상욱KIM, SANGUK
Dept of Life Sciences
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