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Cited 26 time in webofscience Cited 32 time in scopus
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Hybrid scaffold composed of hydrogel/3D-framework and its application as a dopamine delivery system SCIE SCOPUS

Title
Hybrid scaffold composed of hydrogel/3D-framework and its application as a dopamine delivery system
Authors
Kang, KSLee, SIHong, JMLee, JWCho, HYSon, JHPaek, SHCho, DW
Date Issued
2014-02-10
Publisher
ELSEVIER SCIENCE BV
Abstract
Cell-based drug delivery systems (DDSs) have been increasingly exploited because cells can be utilized as a continuous drug delivering system to produce therapeutic molecules over a more extended period compared to the simple drug carriers. Although hydrogels have many advantages for this application, their mechanical properties are generally not desirable to structurally protect implanted cells. Here, we present a three-dimensional (3D) hybrid scaffold with a combination of a 3D framework and a hydrogel to enhance the mechanical properties without chemically altering the transport properties of the hydrogel. Based on the 3D Ormocomp scaffold (framework) fabricated by projection-based microstereolithography with defined parameters, we developed a 3D hybrid scaffold by injection of the mixture of cells and the alginate gel into the internal space of the framework. This hybrid scaffold showed the improved mechanical strength and the framework in the scaffold played the role of an adhesion site for the encapsulated cells during the culture period. Additionally, we confirmed its protection of exogenous human cells from acute immune rejection in a mouse model. Eventually, we demonstrated the feasibility of applying this hybrid scaffold to the treatment of Parkinson's disease as a cell-based DDS. Dopamine released from the 3D hybrid scaffolds encapsulating dopamine-secreting cells for 8 weeks suggested its clinical applicability. Further study on its long-term efficacy is necessary for the clinical applicability of this 3D hybrid scaffold for the treatment of Parkinson's disease. (C) 2013 Elsevier B.V. All rights reserved.
Keywords
Dopamine; Drug delivery system; Hydrogel; Parkinson' s disease; Scaffold; DEEP BRAIN-STIMULATION; ALGINATE HYDROGELS; PARKINSONS-DISEASE; SECRETING CELLS; CROSS-LINKING; GROWTH; GEL; NEUROPROTECTION; ENCAPSULATION; FABRICATION
URI
https://oasis.postech.ac.kr/handle/2014.oak/14619
DOI
10.1016/J.JCONREL.2013.12.002
ISSN
0168-3659
Article Type
Article
Citation
JOURNAL OF CONTROLLED RELEASE, vol. 175, page. 10 - 16, 2014-02-10
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조동우CHO, DONG WOO
Dept of Mechanical Enginrg
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