Morphologic Assessment of Polycaprolactone Scaffolds for Tracheal Transplantation in a Rabbit Model
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- Title
- Morphologic Assessment of Polycaprolactone Scaffolds for Tracheal Transplantation in a Rabbit Model
- Authors
- Joo, YH; Park, JH; Cho, DW; Sun, DI
- Date Issued
- 2013-04
- Publisher
- KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
- Abstract
- The purpose of this study was to clarify whether a polycaprolactone (PCL)-framed porous tracheal scaffold could be used for the replacement of the trachea in rabbits and produce better results in terms of luminal epithelialization. The tracheal scaffold consists of a PCL-framework and a collagen layer. After a longitudinal cervical skin incision, the trachea was exposed and a rectangular defect (1x0.5 cm) was created on the cervical trachea by a scalpel on eight rabbits. PCL-scaffold was trimmed and fixed to defect boundaries with Tisseel. Postoperatively, the site was evaluated endoscopically and histologically. Bronchoscopic examinations at 1 week revealed that implant exposure was recognized in the entire length of the prosthesis. The luminal surface of the implanted scaffold was partially covered at 2 weeks and completely covered at 4 weeks. Histologic data showed that the epithelial lining was nearly completed 1 week after surgery and some inflammatory cells were seen in the submucosa. At 2 weeks, the epithelium was already covered and the migration of inflammatory cells was not observed. However the concentration of cilia was not observed at this week. At 8 weeks there was also a neovascularization with luminal epithelialization. These findings suggest that a PCL-framed porous tracheal scaffold used in our experiment is an effective way to regenerate the epithelium on the surface of an artificial trachea.
- Keywords
- trachea; respiratory mucosa; regeneration; tissue scaffold; MICRO-STEREOLITHOGRAPHY; TISSUE; STENOSIS; RECONSTRUCTION; DEGRADATION; FABRICATION; EXPERIENCE; CARTILAGE; RESECTION; DESIGN
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15254
- DOI
- 10.1007/S13770-013-0358-8
- ISSN
- 1738-2696
- Article Type
- Article
- Citation
- TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 10, no. 2, page. 65 - 70, 2013-04
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