Open Access System for Information Sharing

Login Library

 

Article
Cited 13 time in webofscience Cited 13 time in scopus
Metadata Downloads

Morphologic Assessment of Polycaprolactone Scaffolds for Tracheal Transplantation in a Rabbit Model SCIE SCOPUS KCI

Title
Morphologic Assessment of Polycaprolactone Scaffolds for Tracheal Transplantation in a Rabbit Model
Authors
Joo, YHPark, JHCho, DWSun, DI
Date Issued
2013-04
Publisher
KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC
Abstract
The purpose of this study was to clarify whether a polycaprolactone (PCL)-framed porous tracheal scaffold could be used for the replacement of the trachea in rabbits and produce better results in terms of luminal epithelialization. The tracheal scaffold consists of a PCL-framework and a collagen layer. After a longitudinal cervical skin incision, the trachea was exposed and a rectangular defect (1x0.5 cm) was created on the cervical trachea by a scalpel on eight rabbits. PCL-scaffold was trimmed and fixed to defect boundaries with Tisseel. Postoperatively, the site was evaluated endoscopically and histologically. Bronchoscopic examinations at 1 week revealed that implant exposure was recognized in the entire length of the prosthesis. The luminal surface of the implanted scaffold was partially covered at 2 weeks and completely covered at 4 weeks. Histologic data showed that the epithelial lining was nearly completed 1 week after surgery and some inflammatory cells were seen in the submucosa. At 2 weeks, the epithelium was already covered and the migration of inflammatory cells was not observed. However the concentration of cilia was not observed at this week. At 8 weeks there was also a neovascularization with luminal epithelialization. These findings suggest that a PCL-framed porous tracheal scaffold used in our experiment is an effective way to regenerate the epithelium on the surface of an artificial trachea.
Keywords
trachea; respiratory mucosa; regeneration; tissue scaffold; MICRO-STEREOLITHOGRAPHY; TISSUE; STENOSIS; RECONSTRUCTION; DEGRADATION; FABRICATION; EXPERIENCE; CARTILAGE; RESECTION; DESIGN
URI
https://oasis.postech.ac.kr/handle/2014.oak/15254
DOI
10.1007/S13770-013-0358-8
ISSN
1738-2696
Article Type
Article
Citation
TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 10, no. 2, page. 65 - 70, 2013-04
Files in This Item:
There are no files associated with this item.

qr_code

  • mendeley

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher

조동우CHO, DONG WOO
Dept of Mechanical Enginrg
Read more

Views & Downloads

Browse