DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, ES | - |
dc.contributor.author | Jang, DS | - |
dc.contributor.author | Yang, SY | - |
dc.contributor.author | Lee, MN | - |
dc.contributor.author | Jin, KS | - |
dc.contributor.author | Cha, HJ | - |
dc.contributor.author | Kim, JK | - |
dc.contributor.author | SUNG, YOUNG CHUL | - |
dc.contributor.author | CHOI, KWAN YONG | - |
dc.date.accessioned | 2016-03-31T08:30:43Z | - |
dc.date.available | 2016-03-31T08:30:43Z | - |
dc.date.created | 2013-07-02 | - |
dc.date.issued | 2013-05 | - |
dc.identifier.issn | 2040-3364 | - |
dc.identifier.other | 2013-OAK-0000027751 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/15470 | - |
dc.description.abstract | Nanotechnology has been applied to the development of more effective and compatible drug delivery systems for therapeutic proteins. Human growth hormone (hGH) was fused with a hybrid Fc fragment containing partial Fc domains of human IgD and IgG(4) to produce a long-acting fusion protein. The fusion protein, hGH-hyFc, resulted in the increase of the hydrodynamic diameter (ca. 11 nm) compared with the diameter (ca. 5 nm) of the recombinant hGH. A diblock copolymer membrane with nanopores (average diameter of 14.3 nm) exhibited a constant release rate of hGH-hyFc. The hGH-hyFc protein released in a controlled manner for one month was found to trigger the phosphorylation of Janus kinase 2 (JAK2) in human B lymphocyte and to exhibit an almost identical circular dichroism spectrum to that of the original hGH-hyFc, suggesting that the released fusion protein should maintain the functional and structural integrity of hGH. Thus, the nanoporous release device could be a potential delivery system for the long-term controlled release of therapeutic proteins fused with the hybrid Fc fragment. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | NANOSCALE | - |
dc.title | Controlled release of human growth hormone fused with a human hybrid Fc fragment through a nanoporous polymer membrane | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1039/C3NR00474K | - |
dc.author.google | Kim, ES | - |
dc.author.google | Jang, DS | - |
dc.author.google | Yang, SY | - |
dc.author.google | Lee, MN | - |
dc.author.google | Jin, KS | - |
dc.author.google | Cha, HJ | - |
dc.author.google | Kim, JK | - |
dc.author.google | Sung, YC | - |
dc.author.google | Choi, KY | - |
dc.relation.volume | 5 | - |
dc.relation.issue | 10 | - |
dc.relation.startpage | 4262 | - |
dc.relation.lastpage | 4269 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | Nanoscale | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NANOSCALE, v.10, no.5, pp.4262 - 4269 | - |
dc.identifier.wosid | 000318362400033 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 4269 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 4262 | - |
dc.citation.title | NANOSCALE | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Kim, JK | - |
dc.contributor.affiliatedAuthor | SUNG, YOUNG CHUL | - |
dc.contributor.affiliatedAuthor | CHOI, KWAN YONG | - |
dc.identifier.scopusid | 2-s2.0-84877737261 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 13 | - |
dc.description.scptc | 13 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SUSTAINED-RELEASE | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DIMERIZATION | - |
dc.subject.keywordPlus | FILTRATION | - |
dc.subject.keywordPlus | HGH | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | STATURE | - |
dc.subject.keywordPlus | DESIGN | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
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