A new cucurbit[6]uril-based ion-selective electrode for acetylcholine with high selectivity over choline and related quaternary ammonium ions
SCIE
SCOPUS
- Title
- A new cucurbit[6]uril-based ion-selective electrode for acetylcholine with high selectivity over choline and related quaternary ammonium ions
- Authors
- Kim, H; Oh, J; Jeon, WS; Selvapalam, N; Hwang, I; Ko, YH; Kim, K
- Date Issued
- 2012-06
- Publisher
- Taylor & Francis
- Abstract
- Detection of acetylcholine (ACh(+)) with high sensitivity and selectivity in the presence of interfering ions including choline (Ch(+)) poses a significant analytical challenge. A cucurbit[6]uril derivative, (allyloxy)(12)CB[6], forms a stable 1:1 inclusion complex with ACh(+) but does not interact significantly with Ch(+) in solution. Based on this result, we prepared ion-selective electrodes (ISEs) for ACh(+) using (allyloxy)(12)CB[6] as an ionophore. The (allyloxy)(12)CB[6]-based ISEs detect ACh(+) with unprecedentedly high selectivity over Ch(+) as well as other interfering ions such as dopamine, NH4+, N(CH3)(4)(+) and N(CH2CH3)(4)(+).
- Keywords
- cucurbiturils; host-guest chemistry; ion-selective electrode; acetylcholine; PHARMACEUTICAL-PREPARATION; BULK OPTODES; CUCURBITURIL; DERIVATIVES; MICRODIALYSIS; OPTIMIZATION; CHEMISTRY; MEMBRANE; RELEASE; SENSORS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15964
- DOI
- 10.1080/10610278.2012.688125
- ISSN
- 1061-0278
- Article Type
- Article
- Citation
- SUPRAMOLECULAR CHEMISTRY, vol. 24, no. 7, page. 487 - 491, 2012-06
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