DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, SS | - |
dc.contributor.author | Jeon, BY | - |
dc.contributor.author | Kim, KS | - |
dc.contributor.author | Kwack, JY | - |
dc.contributor.author | Lee, EG | - |
dc.contributor.author | Park, KS | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Cho, SN | - |
dc.date.accessioned | 2016-03-31T08:46:29Z | - |
dc.date.available | 2016-03-31T08:46:29Z | - |
dc.date.created | 2013-02-27 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0969-7128 | - |
dc.identifier.other | 2012-OAK-0000026595 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16020 | - |
dc.description.abstract | Identification of antigens that provide protective immunity via prophylactic and therapeutic vaccination against Mycobacterium tuberculosis is critical for the development of subunit vaccines for tuberculosis (TB). In this study, we performed a head-to-head comparison of seven well-known TB antigens delivered by DNA vaccine, and evaluated their respective immunogenicities and protective efficacies in pre- and post-exposure mouse models. All TB antigens were designed as a chimeric fusion with Flt3-L to enhance antigen-specific T-cell immunity upon vaccination. Prophylactic vaccination with the Flt3L (F)-Mtb32 DNA vaccine elicited significant protection in both the spleen and lungs against M. tuberculosis challenge, comparable to the Bacillus Calmette-Guerin vaccine. F-Ag85A and F-Mtb32 DNA vaccines, in combination with chemotherapy, reduced the bacterial burden to undetectable levels in the lungs of all mice infected with M. tuberculosis. These data collectively indicate that the F-Mtb32 DNA vaccine confers the most efficient protective immunity that suppresses bacterial growth in the active or latent status of M. tuberculosis. Gene Therapy (2012) 19, 570-575; doi:10.1038/gt.2011.140; published online 29 September 2011 | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | GENE THERAPY | - |
dc.subject | tuberculosis | - |
dc.subject | DNA vaccine | - |
dc.subject | Flt3-L | - |
dc.subject | prophylactic model | - |
dc.subject | therapeutic model | - |
dc.subject | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject | PROTECTIVE EFFICACY | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | EFFICIENT PROTECTION | - |
dc.subject | SUBUNIT VACCINE | - |
dc.subject | T-CELLS | - |
dc.subject | INFECTION | - |
dc.subject | IMMUNOGENICITY | - |
dc.subject | PROTEIN | - |
dc.subject | MICE | - |
dc.title | Mtb32 is a promising tuberculosis antigen for DNA vaccination in pre-and post-exposure mouse models | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1038/gt.2011.140 | - |
dc.relation.volume | 19 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 570 | - |
dc.relation.lastpage | 575 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | GENE THERAPY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | GENE THERAPY, v.19, no.5, pp.570 - 575 | - |
dc.identifier.wosid | 000303927300012 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 575 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 570 | - |
dc.citation.title | GENE THERAPY | - |
dc.citation.volume | 19 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-84862121577 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 10 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MYCOBACTERIUM-TUBERCULOSIS | - |
dc.subject.keywordPlus | PROTECTIVE EFFICACY | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | EFFICIENT PROTECTION | - |
dc.subject.keywordPlus | SUBUNIT VACCINE | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | tuberculosis | - |
dc.subject.keywordAuthor | DNA vaccine | - |
dc.subject.keywordAuthor | Flt3-L | - |
dc.subject.keywordAuthor | prophylactic model | - |
dc.subject.keywordAuthor | therapeutic model | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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