Mitochondria and Organismal Longevity
SCIE
SCOPUS
- Title
- Mitochondria and Organismal Longevity
- Authors
- A-Ra-Hwang; Dae-Eun-Jeong; Lee, SJ
- Date Issued
- 2012-11
- Publisher
- Bentham Science
- Abstract
- Mitochondria are essential for various biological processes including cellular energy production. The oxidative stress theory of aging proposes that mitochondria play key roles in aging by generating reactive oxygen species (ROS), which indiscriminately damage macromolecules and lead to an age-dependent decline in biological function. However, recent studies show that increased levels of ROS or inhibition of mitochondrial function can actually delay aging and increase lifespan. The aim of this review is to summarize recent findings regarding the role of mitochondria in organismal aging processes. We will discuss how mitochondria contribute to evolutionarily conserved longevity pathways, including mild inhibition of respiration, dietary restriction, and target of rapamycin (TOR) signaling.
- Keywords
- Mitochondria; Aging; Reactive oxygen species; Dietary restriction; Target of rapamycin (TOR); LIFE-SPAN EXTENSION; HYPOXIA-INDUCIBLE FACTOR; TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA; NEMATODE CAENORHABDITIS-ELEGANS; RESTRICTION-INDUCED LONGEVITY; OXYGEN SPECIES GENERATION; ELECTRON-TRANSPORT CHAIN; GENE-EXPRESSION PROFILE; FEMALE SHR MICE; CALORIE RESTRICTION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16182
- DOI
- 10.2174/138920212803251427
- ISSN
- 1389-2029
- Article Type
- Article
- Citation
- CURRENT GENOMICS, vol. 13, no. 7, page. 519 - 532, 2012-11
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- There are no files associated with this item.
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