DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, HY | - |
dc.contributor.author | Cho, Y | - |
dc.date.accessioned | 2016-03-31T08:55:17Z | - |
dc.date.available | 2016-03-31T08:55:17Z | - |
dc.date.created | 2012-11-13 | - |
dc.date.issued | 1997-05 | - |
dc.identifier.issn | 1072-8368 | - |
dc.identifier.other | 1997-OAK-0000025965 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16307 | - |
dc.description.abstract | The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 Angstrom resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | NATURE STRUCTURAL BIOLOGY | - |
dc.subject | GENE-PRODUCT | - |
dc.subject | RB GENE | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | PROTEIN | - |
dc.subject | PROGRAM | - |
dc.subject | DOMAIN | - |
dc.subject | TFIIB | - |
dc.subject | COMPLEX | - |
dc.subject | BINDING | - |
dc.subject | RECOGNITION | - |
dc.title | Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/nsb0597-390 | - |
dc.author.google | Kim, HY | - |
dc.author.google | Cho, Y | - |
dc.relation.volume | 4 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 390 | - |
dc.relation.lastpage | 395 | - |
dc.contributor.id | 10082321 | - |
dc.relation.journal | NATURE STRUCTURAL BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE STRUCTURAL BIOLOGY, v.4, no.5, pp.390 - 395 | - |
dc.identifier.wosid | A1997WX02800015 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 395 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 390 | - |
dc.citation.title | NATURE STRUCTURAL BIOLOGY | - |
dc.citation.volume | 4 | - |
dc.contributor.affiliatedAuthor | Cho, Y | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 27 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GENE-PRODUCT | - |
dc.subject.keywordPlus | RB GENE | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PROGRAM | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | TFIIB | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
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