DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, KY | - |
dc.contributor.author | Cho, CS | - |
dc.contributor.author | Kim, SS | - |
dc.contributor.author | Sung, HC | - |
dc.contributor.author | Yu, YG | - |
dc.contributor.author | Cho, YJ | - |
dc.date.accessioned | 2016-03-31T08:55:22Z | - |
dc.date.available | 2016-03-31T08:55:22Z | - |
dc.date.created | 2012-11-13 | - |
dc.date.issued | 1999-05 | - |
dc.identifier.issn | 1072-8368 | - |
dc.identifier.other | 1995-OAK-0000025962 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16310 | - |
dc.description.abstract | Glutamate racemase (MurI) is responsible for the synthesis of D-glutamate, an essential building block of the peptidoglycan layer in bacterial cell walls. The crystal structure of glutamate racemase from Aquifex pyrophilus, determined at 2.3 Angstrom resolution, reveals that the enzyme forms a dimer and each monomer consists of two alpha/beta fold domains, a unique structure that has not been observed in other racemases or members of an enolase superfamily, A substrate analog, D-glutamine, binds to the deep pocket formed by conserved residues from two monomers. The structural and mutational analyses allow us to propose a mechanism of metal cofactor-independent glutamate racemase in which two cysteine residues are involved in catalysis. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | NATURE STRUCTURAL BIOLOGY | - |
dc.title | Structure and mechanism of glutamate racemase from Aquifex pyrophilus | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/8223 | - |
dc.author.google | Hwang, KY | - |
dc.author.google | Cho, CS | - |
dc.author.google | Kim, SS | - |
dc.author.google | Sung, HC | - |
dc.author.google | Yu, YG | - |
dc.author.google | Cho, YJ | - |
dc.relation.volume | 6 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 422 | - |
dc.relation.lastpage | 426 | - |
dc.contributor.id | 10082321 | - |
dc.relation.journal | NATURE STRUCTURAL BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE STRUCTURAL BIOLOGY, v.6, no.5, pp.422 - 426 | - |
dc.identifier.wosid | 000080132600011 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 426 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 422 | - |
dc.citation.title | NATURE STRUCTURAL BIOLOGY | - |
dc.citation.volume | 6 | - |
dc.contributor.affiliatedAuthor | Cho, YJ | - |
dc.identifier.scopusid | 2-s2.0-0032915050 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 79 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Letter | - |
dc.subject.keywordPlus | COMPLETE GENOME SEQUENCE | - |
dc.subject.keywordPlus | AMINO-ACID RACEMASE | - |
dc.subject.keywordPlus | MANDELATE RACEMASE | - |
dc.subject.keywordPlus | CATALYTIC RESIDUES | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | ALANINE RACEMASE | - |
dc.subject.keywordPlus | CARBON ACIDS | - |
dc.subject.keywordPlus | ACTIVE-SITE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
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