DC Field | Value | Language |
---|---|---|
dc.contributor.author | Doo-Jin Kim | - |
dc.contributor.author | Kwang-Soon Kim | - |
dc.contributor.author | Mi-Young Song | - |
dc.contributor.author | Sang- Hwan Seo | - |
dc.contributor.author | Su-Jin Kim | - |
dc.contributor.author | Bo-Gie Yang | - |
dc.contributor.author | Myoung-Ho Jang | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-03-31T08:57:13Z | - |
dc.date.available | 2016-03-31T08:57:13Z | - |
dc.date.created | 2012-08-17 | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 1521-6616 | - |
dc.identifier.other | 2012-OAK-0000025768 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16366 | - |
dc.description.abstract | IL-12p40 homodimer is a natural antagonist of IL-12 and IL-23, which are potent pro-inflammatory cytokines required for Th1 and Th17 immune responses, respectively. It has been reported that Th17 response is involved in inflammatory bowel disease (IBD), a chronic disorder of the digestive system with steadily increasing incidence. Here, we investigated the effects of IL-12p40 delivered via recombinant adenovirus (rAd/IL-12p40) or mesenchymal stem cells (MSC/IL-12p40) in a dextran sulfate sodium salt (DSS)-induced colitis model. Injection of rAd/IL-12p40 or MSC/IL-12p40 efficiently attenuated colitis symptoms and tissue damage, Leading to an increased survival rate. Moreover, IL-12p40 delivery suppressed IL-17A, but enhanced IFN-gamma production from mesenteric lymph node cells, supporting the preferential suppression of IL-23 by IL-12p40 homodimer in vitro and the suppression of Th17 responses in vivo. Our results demonstrate that IL-12p40 delivery ameliorates DSS-induced colitis by suppressing IL-17A production and inflammation in the intestinal mucosa, providing an effective new therapeutic strategy for IBDs. (c) 2012 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Elsevier INC | - |
dc.relation.isPartOf | CLINICAL IMMUNOLOGY | - |
dc.subject | IL-12p40 | - |
dc.subject | DSS-induced colitis | - |
dc.subject | Inflammatory bowel disease (IBD) | - |
dc.subject | IL-17A | - |
dc.subject | MESENCHYMAL STEM-CELLS | - |
dc.subject | SODIUM-INDUCED COLITIS | - |
dc.subject | SEVERE CROHNS-DISEASE | - |
dc.subject | TNBS-INDUCED COLITIS | - |
dc.subject | CD4(+) T-CELLS | - |
dc.subject | BOWEL-DISEASE | - |
dc.subject | P40 HOMODIMER | - |
dc.subject | STIMULATORY FACTOR | - |
dc.subject | INTERFERON-GAMMA | - |
dc.subject | MICE | - |
dc.title | Delivery of IL-12p40 ameliorates DSS-induced colitis by suppressing IL-17A expression and inflammation in the intestinal mucosa | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1016/J.CLIM.2012.06.009 | - |
dc.author.google | Kim, DJ | - |
dc.author.google | Kim, KS | - |
dc.author.google | Song, MY | - |
dc.author.google | Seo, SH | - |
dc.author.google | Kim, SJ | - |
dc.author.google | Yang, BG | - |
dc.author.google | Jang, MH | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 144 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 190 | - |
dc.relation.lastpage | 199 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | CLINICAL IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CLINICAL IMMUNOLOGY, v.144, no.3, pp.190 - 199 | - |
dc.identifier.wosid | 000308049100002 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 199 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 190 | - |
dc.citation.title | CLINICAL IMMUNOLOGY | - |
dc.citation.volume | 144 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-84864142890 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 20 | - |
dc.description.scptc | 19 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | SODIUM-INDUCED COLITIS | - |
dc.subject.keywordPlus | SEVERE CROHNS-DISEASE | - |
dc.subject.keywordPlus | TNBS-INDUCED COLITIS | - |
dc.subject.keywordPlus | CD4(+) T-CELLS | - |
dc.subject.keywordPlus | BOWEL-DISEASE | - |
dc.subject.keywordPlus | P40 HOMODIMER | - |
dc.subject.keywordPlus | STIMULATORY FACTOR | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | IL-12p40 | - |
dc.subject.keywordAuthor | DSS-induced colitis | - |
dc.subject.keywordAuthor | Inflammatory bowel disease (IBD) | - |
dc.subject.keywordAuthor | IL-17A | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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