DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yi, JW | - |
dc.contributor.author | Barry, NPE | - |
dc.contributor.author | Furrer, MA | - |
dc.contributor.author | Zava, O | - |
dc.contributor.author | Dyson, PJ | - |
dc.contributor.author | Therrien, B | - |
dc.contributor.author | Kim, BH | - |
dc.date.accessioned | 2016-03-31T08:57:37Z | - |
dc.date.available | 2016-03-31T08:57:37Z | - |
dc.date.created | 2012-08-10 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.other | 2012-OAK-0000025735 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16377 | - |
dc.description.abstract | The self-assembly of 2,4,6-tris(pyridin-4-yl)-1,3,5-triazine (tpt) triangular panels with p-cymene (pPr(i)C(6)H(4)Me) ruthenium building blocks and 2,5-dioxydo-1,4-benzoquinonato (dobq) or 5,8-dioxydo-1,4-naphthoquinonato (donq) bridges, in the presence of a pyrenyl-nucleoside derivatives (pyreneR),. affords the triangular prismatic host guest compounds [(pyrene-R)CRu6(pPr(i)C(6)H(4)Me)(6)(tpt)(2)(dobq)(3)](6+) ([(pyrene-R)C1](6+)) and [(pyrene-R)CRu6(pPr(i)C(6)H(4)Me)(6)(tpt)(2)(donq)(3)](6+) ([(pyrene-R)C2](6+)), respectively. The inclusion of six monosubstituted pyrenyl-nucleosides (pyrene-R1 = 5'-(1-pyrenyl butanoate)-2'-deoxyuridine, pyrene-R2 = 5-fluoro-5'-(1-pyrenyl butanoate)-2'-deoxyuridine, pyrene-R3 = 5'-{N-[1-oxo-4-(1-pyrenyl)butyl]glycyl}-2'-deoxyuridine, pyrene-R4 = 5-fluoro-5'-{N[1-oxo-4-(1-pyrenyl)butyl]-glycyl}2'-deoxyuridine, pyrene-R5 = 5-fluoro-5'-{N-[1-oxo-4-(1-pyrenyl)butyl]-phenylalanyl}-2'-deoxyvuridine, pyrene-R6 = 5-fluoro-5'-{N-[1-oxo-4-(1-pyrenyl)butyl]-phenylalanyl}-2'-deoxyuridine) has been accomplished. The carceplex nature of [(pyrene-R)C1](6+) with the pyrenyl moiety firmly encapsulated in the hydrophobic cavity of the cage with the nucleoside groups pointing outward was confirmed by NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS), while the host-guest nature of [(pyrene-R)C2](6+) was studied in solution by NMR techniques. In contrast to the floxuridine compounds used in the clinic, the host-guest complexes are highly water-soluble. Consequently, the cytotoxicities of these water-soluble compounds have been established using human ovarian A2780 and A2780cisR cancer cells. All the host guest systems are more cytotoxic than the empty cages alone [1][CF3SO3](6) (IC50 = 23 mu M) and [2][CF3SO3](6) (IC50 = 10 mu M), the most active compound [pyrene-R4C1][CF3SO3](6) being 2 orders of magnitude more cytotoxic (IC50 = 0.3 mu M) on these human ovarian cancer cell lines (A2780 and A2780cisR). | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | American Chemical Society | - |
dc.relation.isPartOf | BIOCONJUGATE CHEMISTRY | - |
dc.subject | RUTHENIUM COMPLEXES | - |
dc.subject | ANTICANCER ACTIVITY | - |
dc.subject | NUCLEOSIDE ANALOGS | - |
dc.subject | DRUG-RELEASE | - |
dc.subject | PRODRUGS | - |
dc.subject | 5-FLUOROURACIL | - |
dc.subject | ENCAPSULATION | - |
dc.subject | PERMEABILITY | - |
dc.subject | MECHANISMS | - |
dc.subject | STRATEGIES | - |
dc.title | Delivery of Floxuridine Derivatives to Cancer Cells by Water-Soluble Organometallic Cages | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1021/bc200472n | - |
dc.author.google | Yi, JW | - |
dc.author.google | Barry, NPE | - |
dc.author.google | Furrer, MA | - |
dc.author.google | Zava, O | - |
dc.author.google | Dyson, PJ | - |
dc.author.google | Therrien, B | - |
dc.relation.volume | 23 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 461 | - |
dc.relation.lastpage | 471 | - |
dc.contributor.id | 10142056 | - |
dc.relation.journal | BIOCONJUGATE CHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCONJUGATE CHEMISTRY, v.23, no.3, pp.461 - 471 | - |
dc.identifier.wosid | 000301700200017 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 471 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 461 | - |
dc.citation.title | BIOCONJUGATE CHEMISTRY | - |
dc.citation.volume | 23 | - |
dc.contributor.affiliatedAuthor | Kim, BH | - |
dc.identifier.scopusid | 2-s2.0-84863337900 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 44 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RUTHENIUM COMPLEXES | - |
dc.subject.keywordPlus | DRUG-RELEASE | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | PRODRUGS | - |
dc.subject.keywordPlus | 5-FLUOROURACIL | - |
dc.subject.keywordPlus | ENCAPSULATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
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