T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation
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SCOPUS
- Title
- T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation
- Authors
- Kataru, RP; Kim, H; Jang, C; Choi, DK; Koh, BI; Kim, M; Gollamudi, S; Kim, YK; Lee, SH; Koh, GY
- Date Issued
- 2011-01-28
- Publisher
- CELL PRESS
- Abstract
- Lymph node lymphatic vessels (LNLVs) serve as a conduit to drain antigens from peripheral tissues to within the lymph nodes. LNLV density is known to be positively regulated by vascular endothelial growth factors secreted by B cells, macrophages, and dendritic cells (DCs). Here, we show that LNLV formation was negatively regulated by T cells. In both steady and inflammatory states, the density of LNLVs was increased in the absence of T cells but decreased when T cells were restored. Interferon-gamma secretion by T cells suppressed lymphatic-specific genes in lymphatic endothelial cells and consequently caused marked reduction in LNLV formation. When T cells were depleted, recruitment of antigen-carrying DCs to LNs was augmented, reflecting a compensatory mechanism for antigen presentation to T cells through increased LNLVs. Thus, T cells maintain the homeostatic balance of LNLV density through a negative paracrine action of interferon-gamma.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16738
- DOI
- 10.1016/J.IMMUNI.2010.12.016
- ISSN
- 1074-7613
- Article Type
- Article
- Citation
- IMMUNITY, vol. 34, no. 1, page. 96 - 107, 2011-01-28
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