Identification of a peptoid inhibitor of the proteasome 19S regulatory particle
SCIE
SCOPUS
- Title
- Identification of a peptoid inhibitor of the proteasome 19S regulatory particle
- Authors
- Lim, HS; Archer, CT; Kodadek, T
- Date Issued
- 2007-06-27
- Publisher
- American Chemical Society
- Abstract
- The first chemical inhibitor of the 19S regulatory particle (RP) of the proteasome is described. The molecule was identified by screening a library of nucleoside-capped peptoids for binding to the yeast 26S proteasome in a crude extract. The hit was resynthesized and shown to block 19S RP-mediated protein unfolding in vitro and proteasome-mediated turnover of p27 in HeLa cells.
- Keywords
- TRANSCRIPTION; LIBRARIES; ATPASES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16846
- DOI
- 10.1021/JA072027P
- ISSN
- 0002-7863
- Article Type
- Article
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, no. 25, page. 7750 - +, 2007-06-27
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