Periodate-triggered cross-linking reveals Sug2/Rpt4 as the molecular target of a peptoid inhibitor of the 19S proteasome regulatory particle
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SCOPUS
- Title
- Periodate-triggered cross-linking reveals Sug2/Rpt4 as the molecular target of a peptoid inhibitor of the 19S proteasome regulatory particle
- Authors
- Lim, HS; Cai, D; Archer, CT; Kodadek, T
- Date Issued
- 2007-10-31
- Publisher
- American Chemical Society
- Abstract
- This study describes the identification of the protein target of the first chemical inhibitor (RIP-1) of t he 19S regulatory particle (RP) of the 25S proteasome. Periodate-triggered chemical cross-linking of DOPA-conjugate RIP-1 and the 26S proteasome identified Sug2/Rpt4, one of the six ATPases in the 19S as the molecular target of RIP-1 for Sug2/Rpt4 was domonstarated by examining cross-linking reactions with each ATPase if tge 19S RP. RIP-1 should provide a useful biological tool to probe the various biological roles of Sug2/Rpt4.
- Keywords
- PROTEIN COMPLEXES; IDENTIFICATION; ATPASES; BINDING
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16847
- DOI
- 10.1021/JA075469+
- ISSN
- 0002-7863
- Article Type
- Article
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 129, no. 43, page. 12936 - +, 2007-10-31
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