DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hesung Now | - |
dc.contributor.author | Yoo, JY | - |
dc.date.accessioned | 2016-03-31T09:13:41Z | - |
dc.date.available | 2016-03-31T09:13:41Z | - |
dc.date.created | 2012-02-13 | - |
dc.date.issued | 2011-09-30 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 2011-OAK-0000024741 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16853 | - |
dc.description.abstract | The cellular RIG-I-like receptor (RLR) senses pathogenic RNA molecular patterns and transmits signals for type I interferon (IFN) production. It acts as a center for antiviral responses, and large numbers of RIG-I (retinoic acid inducible gene-I) interacting proteins are identified as signaling regulators. In the present study, we report PRKRIR, a negative regulator of PKR inhibitor, as a novel RIG-I interacting protein. In HEK293FT cells, PRKRIR synergistically enhances type I IFN production mediated by a signal activated- or constitutively active form of RIG-I. The C-terminal domain of the PRKRIR was required for physical interaction and the signal augmentation. The PRKRIR blocks poly-ubiquitination and protein degradation of RIG-I, thereby increasing cellular levels of RIG-I proteins. Furthermore, overexpression of PRKRIR, along with a signal activated- or constitutively active form of RIG-I, efficiently inhibits virus replication in the infected host. In conclusion, PRKRIR provides a novel positive regulator controlling the RIG-I-IFN production system through protein stability control. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | New York, Academic Press. | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | RIG-I | - |
dc.subject | PRKRIR | - |
dc.subject | Virus | - |
dc.subject | Antiviral | - |
dc.subject | Ubiquitination | - |
dc.subject | IFN | - |
dc.subject | Anti-viral signaling | - |
dc.subject | RNA virus | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | UBIQUITIN LIGASE | - |
dc.subject | ADAPTER PROTEIN | - |
dc.subject | INNATE IMMUNITY | - |
dc.subject | GENE-I | - |
dc.subject | HELICASE | - |
dc.subject | ACTIVATION | - |
dc.subject | ISGYLATION | - |
dc.subject | P52(RIPK) | - |
dc.title | A protein-kinase, IFN-inducible double-stranded RNA dependent inhibitor and repressor of p58 (PRKRIR) enhances type I IFN-mediated antiviral response through the stability control of RIG-I protein | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.BBRC.2011.08.127 | - |
dc.author.google | Now, H | - |
dc.author.google | Yoo, JY | - |
dc.relation.volume | 413 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 487 | - |
dc.relation.lastpage | 493 | - |
dc.contributor.id | 10114821 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.413, no.3, pp.487 - 493 | - |
dc.identifier.wosid | 000295908500017 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 493 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 487 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 413 | - |
dc.contributor.affiliatedAuthor | Yoo, JY | - |
dc.identifier.scopusid | 2-s2.0-80053336032 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 3 | - |
dc.description.scptc | 3 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | ADAPTER PROTEIN | - |
dc.subject.keywordPlus | HELICASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | P58(IPK) | - |
dc.subject.keywordPlus | LGP2 | - |
dc.subject.keywordAuthor | RIG-I | - |
dc.subject.keywordAuthor | PRKRIR | - |
dc.subject.keywordAuthor | Virus | - |
dc.subject.keywordAuthor | Antiviral | - |
dc.subject.keywordAuthor | Ubiquitination | - |
dc.subject.keywordAuthor | IFN | - |
dc.subject.keywordAuthor | Anti-viral signaling | - |
dc.subject.keywordAuthor | RNA virus | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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