DC Field | Value | Language |
---|---|---|
dc.contributor.author | Qingye Lu | - |
dc.contributor.author | Hwang, DS | - |
dc.contributor.author | Yang Liu | - |
dc.contributor.author | Hongbo Zeng | - |
dc.date.accessioned | 2016-03-31T09:20:28Z | - |
dc.date.available | 2016-03-31T09:20:28Z | - |
dc.date.created | 2011-12-15 | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.other | 2011-OAK-0000024404 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/17035 | - |
dc.description.abstract | Protective coating of the byssus of mussels (Mytilus sp.) has been suggested as a new paradigm of medical coating due to its high extensibility and hardness co-existence without their mutual detriment. The only known biomacromolecule in the extensible and tough coating on the byssus is mussel foot protein-1 (mfp-1), which is made up with positively charged residues (similar to 20 mol%) and lack of negatively charged residues. Here, adhesion and molecular interaction mechanisms of Mytilus californianus foot protein-1 (mcfp-1) from California blue mussel were investigated using a surface forces apparatus (SFA) in buffer solutions of different ionic concentrations (0.2-0.7 M) and pHs (3.0-5.5). Strong and reversible cohesion between opposed positively charged mcfp-1 films was measured in 0.1 M sodium acetate buffer with 0.1 M KNO3. Cohesion of mcfp-1 was gradually reduced with increasing the ionic strength, but was not changed with pH variations. Oxidation of 3,4-dihydroxyphenylalanine (DOPA) residues of mcfp-1, a key residue for adhesive and coating proteins of mussel, didn't change the cohesion strength of mcfp-1 films, but the addition of chemicals with aromatic groups (i.e., aspirin and 4-methylcatechol) increased the cohesion. These results suggest that the cohesion of mcfp-1 films is mainly mediated by cation-it interactions between the positively charged residues and benzene rings of DOPA and other aromatic amino acids (similar to 20 mol% of total amino acids of mcfp-1), and pi-pi interactions between the phenyl groups in mcfp-1. The adhesion mechanism obtained for the mcfp-1 proteins provides important insight into the design and development of functional biomaterials and coatings mimicking the extensible and robust mussel cuticle coating. (C) 2011 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.title | Molecular interactions of mussel protective coating protein, mcfp-1, from Mytilus californianus | - |
dc.type | Article | - |
dc.contributor.college | 해양대학원 | - |
dc.identifier.doi | 10.1016/J.BIOMATERIALS.2011.11.021 | - |
dc.author.google | Lu Q., Hwang D.S., Liu Y., Zeng H. | - |
dc.relation.volume | 33 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 1903 | - |
dc.relation.lastpage | 1911 | - |
dc.contributor.id | 10167197 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.33, no.6, pp.1903 - 1911 | - |
dc.identifier.wosid | 000299986200022 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1911 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1903 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 33 | - |
dc.contributor.affiliatedAuthor | Hwang, DS | - |
dc.identifier.scopusid | 2-s2.0-83555178364 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 46 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CATION-PI INTERACTIONS | - |
dc.subject.keywordPlus | 2 MICA SURFACES | - |
dc.subject.keywordPlus | ADHESIVE PROTEIN | - |
dc.subject.keywordPlus | AROMATIC RINGS | - |
dc.subject.keywordPlus | DOPA | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | FORCES | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | REDOX | - |
dc.subject.keywordAuthor | Mcfp-1 | - |
dc.subject.keywordAuthor | Cation-pi interaction | - |
dc.subject.keywordAuthor | Bioadhesion | - |
dc.subject.keywordAuthor | Protein interactions | - |
dc.subject.keywordAuthor | Surface forces apparatus | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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