DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, BK | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Choi, JH | - |
dc.contributor.author | Kim, CH | - |
dc.contributor.author | Kim, KS | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Lee, YM | - |
dc.contributor.author | Moffett, JR | - |
dc.contributor.author | Kwon, BS | - |
dc.date.accessioned | 2016-03-31T09:22:39Z | - |
dc.date.available | 2016-03-31T09:22:39Z | - |
dc.date.created | 2011-09-20 | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 1043-4666 | - |
dc.identifier.other | 2011-OAK-0000024233 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/17095 | - |
dc.description.abstract | 4-1BB (CD137) is a powerful T-cell costimulatory molecule in the treatment of virus infections and tumors, but recent studies have also uncovered regulatory functions of 4-1BB signaling. Since 4-1BB triggering suppresses autoimmunity by accumulating indoleamine 2,3-dioxygenase (IDO) in dendritic cells (DCs) in an interferon (IFN)-gamma-dependent manner, we asked whether similar molecular and cellular changes were induced by 4-1BB triggering in virus-infected mice. 4-1BB triggering increased IFN-gamma and IDO, and suppressed CD4(+) T cells, in C57BL/6 mice infected with the type 1 KOS strain of Herpes simplex virus (HSV-1), as it does in an autoimmune disease model. Detailed analysis of the CD4(+) T suppression showed that freshly activated CD62L(high) T cells underwent apoptosis in the early phase of suppression, and CD62L(low) effector/memory T cells in the later phase. Although 4-1 BB triggering resulted in similar cellular changes - increased CD8(+) T and decreased CD4(+) T cells, it had different effects on mortality in mice infected with HSV-1 RE, influenza, and Japanese encephalitis virus (JEV); it increased mortality in influenza-infected mice but decreased it in JEV-infected mice. Since the dominant type of immune cell generated to protect the host was different for each virus - CD4(+) T cells and neutrophils in HSV-1 RE infection, both CD4(+) T and CD8(+). T cells in influenza infection, and a crucial role for B cells in JEV infection, 4-1BB triggering resulted in different therapeutic outcomes. We conclude that the therapeutic outcome of 4-1BB triggering is determined by whether the protective immunity generated against the virus was beneficially altered by the 4-1BB triggering. (C) 2011 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | CYTOKINE | - |
dc.subject | 4-1BB (CD137) | - |
dc.subject | CD4(+) T cells | - |
dc.subject | CD8(+) T cells | - |
dc.subject | Costimulation | - |
dc.subject | Suppression | - |
dc.subject | T-CELL RESPONSES | - |
dc.subject | JAPANESE ENCEPHALITIS-VIRUS | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | MONOCLONAL-ANTIBODIES | - |
dc.subject | EXPRESSION | - |
dc.subject | SURVIVAL | - |
dc.subject | CD8(+) | - |
dc.subject | MICE | - |
dc.subject | SUPPRESSION | - |
dc.subject | INFECTION | - |
dc.title | Unified immune modulation by 4-1BB triggering leads to diverse effects on disease progression in vivo | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1016/J.CYTO.2011.05.015 | - |
dc.author.google | Choi, BK | - |
dc.author.google | Kim, YH | - |
dc.author.google | Choi, JH | - |
dc.author.google | Kim, CH | - |
dc.author.google | Kim, KS | - |
dc.author.google | Sung, YC | - |
dc.author.google | Lee, YM | - |
dc.author.google | Moffett, JR | - |
dc.author.google | Kwon, BS | - |
dc.relation.volume | 55 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 420 | - |
dc.relation.lastpage | 428 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | CYTOKINE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | CYTOKINE, v.55, no.3, pp.420 - 428 | - |
dc.identifier.wosid | 000294034100015 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 428 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 420 | - |
dc.citation.title | CYTOKINE | - |
dc.citation.volume | 55 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-79960892035 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.description.scptc | 4 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | T-CELL RESPONSES | - |
dc.subject.keywordPlus | JAPANESE ENCEPHALITIS-VIRUS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODIES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CD8(+) | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordAuthor | 4-1BB (CD137) | - |
dc.subject.keywordAuthor | CD4(+) T cells | - |
dc.subject.keywordAuthor | CD8(+) T cells | - |
dc.subject.keywordAuthor | Costimulation | - |
dc.subject.keywordAuthor | Suppression | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
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