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Cited 6 time in webofscience Cited 7 time in scopus
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Rab3d Is Required for Xenopus Anterior Neurulation by Regulating Noggin Secretion SCIE SCOPUS

Title
Rab3d Is Required for Xenopus Anterior Neurulation by Regulating Noggin Secretion
Authors
Kim, HHan, JK
Date Issued
2011-06
Publisher
WILEY-BLACKWELL
Abstract
Rab3d is a member of the Ras-related small GTPase family of secretory Rab, Rab3. In this study, we showed that Xenopus Rab3d is expressed specifically in the anterior border of the neural plate when the neural plate converges and folds to initiate neural tube formation. Morpholino-mediated knockdown of Rab3d resulted in neurulation defects both in neural plate convergence and folding. Interestingly, perturbation of BMP signaling rescued neurulation defects of Rab3d morphants, suggesting that Rab3d inhibits BMP signaling during neurulation. By secretion assay in the Xenopus animal cap, we found that Rab3d specifically regulates secretion of a BMP antagonist, Noggin, but not Chordin and Wnts. We also found that Rab3d is co-localized with Noggin and that this interaction is dependent on the GTP/GDP cycle of Rab3d. Collectively, these findings suggest that Rab3d-mediated secretion regulation of a BMP antagonist, Noggin, is one of the mechanisms of BMP antagonism during Xenopus anterior neurulation. Developmental Dynamics 240:1430-1439, 2011. (C) 2011 Wiley-Liss, Inc.
Keywords
Xenopus; neurulation; Rab3d; Noggin; exocytosis; NEURAL-TUBE CLOSURE; PLANAR-CELL-POLARITY; CONVERGENT EXTENSION; PANCREATIC ACINI; EMBRYOS; PROTEIN; INDUCTION; MEMBRANE; GRANULES; DEFECTS
URI
https://oasis.postech.ac.kr/handle/2014.oak/17322
DOI
10.1002/DVDY.22643
ISSN
1058-8388
Article Type
Article
Citation
DEVELOPMENTAL DYNAMICS, vol. 240, no. 6, page. 1430 - 1439, 2011-06
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한진관HAN, JIN KWAN
Dept of Life Sciences
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