Surface structures and osteoblast response of hydrothermally produced CaTiO3 thin film on Ti-13Nb-13Zr alloy
SCIE
SCOPUS
- Title
- Surface structures and osteoblast response of hydrothermally produced CaTiO3 thin film on Ti-13Nb-13Zr alloy
- Authors
- Park, JW; Tustusmi, Y; Lee, CS; Park, CH; Kim, YJ; Jang, JH; Khang, D; Im, YM; Doi, H; Nomura, N; Hanawa, T
- Date Issued
- 2011-06-15
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- This study investigated the surface characteristics and in vitro biocompatibility of a titanium (Ti) oxide layer incorporating calcium ions (Ca) obtained by hydrothermal treatment with or without post heat-treatment in the Ti-13Nb-13Zr alloy. The surface characteristics were evaluated by scanning electron microscopy, thin-film X-ray diffractometry, X-ray photoelectron spectroscopy, atomic force microscopy and contact angle measurements. In vitro biocompatibility of the Ca-containing surfaces was assessed in comparison with untreated surfaces using a pre-osteoblast cell line. Hydrothermal treatment produced a crystalline CaTiO3 layer. Post heat-treatment at 400 degrees C for 2 h in air significantly decreased water contact angles in the CaTiO3 layer (p < 0.001). The Ca-incorporated alloy surfaces displayed markedly increased cell viability and ALP activity compared with untreated surfaces (p < 0.001), and also an upregulated expression of various integrin genes (alpha 1, alpha 2, alpha 5, alpha v, beta 1 and beta 3) at an early incubation time-point. Post heat-treatment further increased attachment and ALP activity in cells grown on Ca-incorporated Ti-13Nb-13Zr alloy surfaces. The results indicate that the Ca-incorporated oxide layer produced by hydrothermal treatment and a simple post heat-treatment may be effective in improving bone healing in Ti-13Nb-13Zr alloy implants by enhancing the viability and differentiation of osteoblastic cells. (C) 2011 Elsevier B. V. All rights reserved.
- Keywords
- Ti-13Nb-13Zr alloy; Calcium ion; Surface hydrophilicity; Osteoblast; Hydrothermal treatment; CALCIUM-ION IMPLANTATION; TOTAL HIP-ARTHROPLASTY; TITANIUM-ALLOY; IN-VITRO; MECHANICAL-PROPERTIES; GLOW-DISCHARGE; RABBIT TIBIAE; CELL-ADHESION; ZERO CHARGE; METAL-IONS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17388
- DOI
- 10.1016/J.APSUSC.2011.04.054
- ISSN
- 0169-4332
- Article Type
- Article
- Citation
- APPLIED SURFACE SCIENCE, vol. 257, no. 17, page. 7856 - 7863, 2011-06-15
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