Neurexin-Neuroligin Transsynaptic Interaction Mediates Learning-Related Synaptic Remodeling and Long-Term Facilitation in Aplysia
SCIE
SCOPUS
- Title
- Neurexin-Neuroligin Transsynaptic Interaction Mediates Learning-Related Synaptic Remodeling and Long-Term Facilitation in Aplysia
- Authors
- Choi, YB; Li, HL; Kassabov, SR; Jin, I; Puthanveettil, SV; Karl, KA; Lu, Y; Kim, JH; Bailey, CH; K; el, ER
- Date Issued
- 2011-05-12
- Publisher
- CELL PRESS
- Abstract
- Neurexin and neuroligin, which undergo heterophilic interactions with each other at the synapse, are mutated in some patients with autism spectrum disorder, a set of disorders characterized by deficits in social and emotional learning. We have explored the role of neurexin and neuroligin at sensory-to-motor neuron synapses of the gill-withdrawal reflex in Aplysia, which undergoes sensitization, a simple form of learned fear. We find that depleting neurexin in the presynaptic sensory neuron or neuroligin in the postsynaptic motor neuron abolishes both long-term facilitation and the associated presynaptic growth induced by repeated pulses of serotonin. Moreover, introduction into the motor neuron of the R451C mutation of neuroligin-3 linked to autism spectrum disorder blocks both intermediate-term and long-term facilitation. Our results suggest that activity-dependent regulation of the neurexin-neuroligin interaction may govern transsynaptic signaling required for the storage of long-term memory, including emotional memory that may be impaired in autism spectrum disorder.
- Keywords
- LOCAL PROTEIN-SYNTHESIS; ADHESION MOLECULES; ALPHA-NEUREXINS; BETA-NEUREXINS; MOTOR SYNAPSES; MEMORY STORAGE; PLASTICITY; AUTISM; GENES; INTERMEDIATE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17401
- DOI
- 10.1016/J.NEURON.2011.03.020
- ISSN
- 0896-6273
- Article Type
- Article
- Citation
- NEURON, vol. 70, no. 3, page. 468 - 481, 2011-05-12
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