Bioconjugation of L-3,4-Dihydroxyphenylalanine Containing Protein with a Polysaccharide
SCIE
SCOPUS
- Title
- Bioconjugation of L-3,4-Dihydroxyphenylalanine Containing Protein with a Polysaccharide
- Authors
- Ayyadurai, N; Prabhu, NS; Deepankumar, K; Jang, YJ; Chitrapriya, N; Song, E; Lee, N; Kim, SK; Kim, BG; Soundrarajan, N; Lee, S; Cha, HJ; Budisa, N; Yun, H
- Date Issued
- 2011-04
- Publisher
- AMER CHEMICAL SOC
- Abstract
- We describe the simple bioconjugation strategy in combination of periodate chemistry and unnatural amino acid incorporation. The residue specific incorporation of 3,4-dihydroxy-L-phenylalanine can alter the properties of protein to conjugate into the polymers. The homogeneously modified protein will yield quinone residues that are covalently conjugated to nucleophilic groups of the amino polysaccharide. This novel approach holds great promise for widespread use to prepare protein conjugates and synthetic biology applications.
- Keywords
- IN-VIVO; CHEMISTRY; VACCINES; BIOLOGY; CELLS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17447
- DOI
- 10.1021/BC2000066
- ISSN
- 1043-1802
- Article Type
- Article
- Citation
- BIOCONJUGATE CHEMISTRY, vol. 22, no. 4, page. 551 - 555, 2011-04
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- There are no files associated with this item.
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