DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jun, DJ | - |
dc.contributor.author | Kim, J | - |
dc.contributor.author | Jung, SY | - |
dc.contributor.author | Song, R | - |
dc.contributor.author | Noh, JH | - |
dc.contributor.author | Park, YS | - |
dc.contributor.author | RYU, SUNG HO | - |
dc.contributor.author | KIM, JOUNG HUN | - |
dc.contributor.author | Kong, YY | - |
dc.contributor.author | Chung, JM | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T09:39:38Z | - |
dc.date.available | 2016-03-31T09:39:38Z | - |
dc.date.created | 2009-05-29 | - |
dc.date.issued | 2007-12-28 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.other | 2007-OAK-0000023574 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/17450 | - |
dc.description.abstract | Extracellular ATP has recently been identified as an important regulator of cell death in response to pathological insults. When SN4741 cells, which are dopaminergic neurons derived from the substantia nigra of transgenic mouse embryos, are exposed to ATP, cell death occurs. This cell death is associated with prominent cell swelling, loss of ER integrity, the formation of many large cytoplasmic vacuoles, and subsequent cytolysis and DNA release. In addition, the cleavage of caspase-3, a hallmark of apoptosis, is induced by ATP treatment. However, caspase inhibitors do not overcome ATP-induced cell death, indicating that both necrosis and apoptosis are associated with ATP-induced cell death and suggesting that a necrotic event might override the apoptotic process. In this study we also found that P2X(7) receptors (P2X(7)Rs) are abundantly expressed in SN4741 cells, and both ATP-induced swelling and cell death are reversed by pretreatment with the P2X(7)Rs antagonist, KN62, or by knock-down of P2X(7)Rs with small interfering RNAs. Therefore, extracellular ATP release from injured tissues may act as an accelerating factor in necrotic SN4741 dopaminergic cell death via P2X(7)Rs. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLO | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.title | Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X(7) receptors | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1074/jbc.M707915200 | - |
dc.author.google | Jun, DJ | - |
dc.author.google | Kim, J | - |
dc.author.google | Jung, SY | - |
dc.author.google | Song, R | - |
dc.author.google | Noh, JH | - |
dc.author.google | Park, YS | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Kim, JH | - |
dc.author.google | Kong, YY | - |
dc.author.google | Chung, JM | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 282 | - |
dc.relation.issue | 52 | - |
dc.relation.startpage | 37350 | - |
dc.relation.lastpage | 37358 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.282, no.52, pp.37350 - 37358 | - |
dc.identifier.wosid | 000251833600009 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 37358 | - |
dc.citation.number | 52 | - |
dc.citation.startPage | 37350 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 282 | - |
dc.contributor.affiliatedAuthor | RYU, SUNG HO | - |
dc.contributor.affiliatedAuthor | KIM, JOUNG HUN | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-38049110607 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 49 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ALA POLYMORPHISM | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | IMPAIRS | - |
dc.subject.keywordPlus | NEUROPROTECTION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ANTAGONISTS | - |
dc.subject.keywordPlus | MODULATION | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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