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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Im, J | - |
| dc.contributor.author | Biswas, G | - |
| dc.contributor.author | Kim, W | - |
| dc.contributor.author | Kim, KT | - |
| dc.contributor.author | Chung, SK | - |
| dc.date.accessioned | 2016-03-31T09:46:07Z | - |
| dc.date.available | 2016-03-31T09:46:07Z | - |
| dc.date.created | 2011-04-18 | - |
| dc.date.issued | 2011-03-20 | - |
| dc.identifier.issn | 0253-2964 | - |
| dc.identifier.other | 2011-OAK-0000023406 | - |
| dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/17544 | - |
| dc.description.abstract | 5-Fluorouracil (5-FU), an anticancer agent was covalently attached to the recently developed sorbitol-based G8 transporter, and the conjugate (7) with FITC was found to have an affinity toward mitochondria and to readily cross BBB to gain an entry into mouse brain. Measured by IC50, the conjugate (9) without the fluorophore showed enhanced cytotoxic activity toward two types of multidrug-resistant cell lines. These results strongly suggest that the sorbitol-based G8 transporter can be utilized as a good CNS delivery vector. | - |
| dc.description.statementofresponsibility | X | - |
| dc.language | English | - |
| dc.publisher | KOREAN CHEMICAL SOC | - |
| dc.relation.isPartOf | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
| dc.title | A Blood-brain Barrier Permeable Derivative of 5-Fluorouracil: Preparation, Intracellular Localization, and Mouse Tissue Distribution | - |
| dc.type | Article | - |
| dc.contributor.college | 융합생명공학부 | - |
| dc.identifier.doi | 10.5012/BKCS.2011.32.3.873 | - |
| dc.author.google | Im, J | - |
| dc.author.google | Biswas, G | - |
| dc.author.google | Kim, W | - |
| dc.author.google | Kim, KT | - |
| dc.author.google | Chung, SK | - |
| dc.relation.volume | 32 | - |
| dc.relation.issue | 3 | - |
| dc.relation.startpage | 873 | - |
| dc.relation.lastpage | 879 | - |
| dc.contributor.id | 10104775 | - |
| dc.relation.journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
| dc.relation.index | SCI급, SCOPUS 등재논문 | - |
| dc.relation.sci | SCI | - |
| dc.collections.name | Journal Papers | - |
| dc.type.rims | ART | - |
| dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.32, no.3, pp.873 - 879 | - |
| dc.identifier.wosid | 000288832700021 | - |
| dc.date.tcdate | 2019-01-01 | - |
| dc.citation.endPage | 879 | - |
| dc.citation.number | 3 | - |
| dc.citation.startPage | 873 | - |
| dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
| dc.citation.volume | 32 | - |
| dc.contributor.affiliatedAuthor | Kim, KT | - |
| dc.identifier.scopusid | 2-s2.0-79953233822 | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalClass | 1 | - |
| dc.description.wostc | 8 | - |
| dc.description.scptc | 9 | * |
| dc.date.scptcdate | 2018-05-121 | * |
| dc.type.docType | Article | - |
| dc.subject.keywordPlus | CONTAINING MOLECULAR TRANSPORTERS | - |
| dc.subject.keywordPlus | FLUOROPYRIMIDINE CARBAMATE | - |
| dc.subject.keywordPlus | CAPECITABINE | - |
| dc.subject.keywordPlus | MECHANISMS | - |
| dc.subject.keywordPlus | CANCER | - |
| dc.subject.keywordPlus | DELIVERY | - |
| dc.subject.keywordPlus | DESIGN | - |
| dc.subject.keywordAuthor | Blood-brain barrier | - |
| dc.subject.keywordAuthor | G8 molecular transporter | - |
| dc.subject.keywordAuthor | CNS delivery | - |
| dc.subject.keywordAuthor | anti-cancer agent | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
| dc.relation.journalResearchArea | Chemistry | - |
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Related Researcher
- 김경태KIM, KYONG TAI
- Dept of Life Sciences