DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, WS | - |
dc.contributor.author | Bae, Y | - |
dc.contributor.author | Chung, DH | - |
dc.contributor.author | Choi, YL | - |
dc.contributor.author | Kim, BK | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Choi, EY | - |
dc.contributor.author | Park, SH | - |
dc.contributor.author | Jung, KC | - |
dc.date.accessioned | 2016-03-31T12:13:58Z | - |
dc.date.available | 2016-03-31T12:13:58Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2004-10 | - |
dc.identifier.issn | 0953-8178 | - |
dc.identifier.other | 2004-OAK-0000004567 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/17693 | - |
dc.description.abstract | Despite the fact that major histocompatibility complex class II transactivator (CIITA) has been known to be involved in Th1/Th2 balance in addition to its major role as a master regulator for the expression of MHC class II genes, the exact role of CIITA in Th1/Th2 balance is still controversial. To investigate whether the Th1/Th2 balance could be modulated by T cell specific expression of CIITA, we generated CIITA-transgenic mice, in which the CIITA expression is controlled by the distal promoter of p56(lck), resulting in constitutive expression of CIITA predominantly in peripheral T cells. Naive CD4(+) T cells from CIITA-transgenic mice exhibited a low level of IFN-gamma secretion as well as impaired Th1 polarization in vitro, while IL-4 secretion was enhanced under Th2 condition. In addition, the development of experimental autoimmune encephalomyelitis (EAE), a prototype of Th1-mediated disease, was repressed in CIITA-transgenic mice. Resistance to EAE was correlated with reduced production of IFN-gamma in response to MOG(35-55), while the proliferation of MOG(35-55)-specific T cells was not affected in CIITA-transgenic mice. Together, these data demonstrate that overexpression of CIITA in T cells inhibits Th1 differentiation and function, suggesting that the expression of CIITA in T cells might play a role in the regulation of the Th1/Th2 balance during the T cell lineage commitment. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOLOGY | - |
dc.subject | experimental autoimmune encephalomyelitis | - |
dc.subject | IFN-gamma | - |
dc.subject | MHC class II | - |
dc.subject | transgenic mouse | - |
dc.subject | CLASS-II TRANSACTIVATOR | - |
dc.subject | INTERFERON-GAMMA | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | FAS LIGAND | - |
dc.subject | MICE | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | IL-4 | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | LYMPHOCYTES | - |
dc.subject | PROMOTER | - |
dc.title | T cell expression of CIITA represses Th1 immunity | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1093/intimm/dxh132 | - |
dc.author.google | Park, WS | - |
dc.author.google | Bae, Y | - |
dc.author.google | Chung, DH | - |
dc.author.google | Choi, YL | - |
dc.author.google | Kim, BK | - |
dc.author.google | Sung, YC | - |
dc.author.google | Choi, EY | - |
dc.author.google | Park, SH | - |
dc.author.google | Jung, KC | - |
dc.relation.volume | 16 | - |
dc.relation.issue | 10 | - |
dc.relation.startpage | 1355 | - |
dc.relation.lastpage | 1364 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | INTERNATIONAL IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOLOGY, v.16, no.10, pp.1355 - 1364 | - |
dc.identifier.wosid | 000224079800001 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1364 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1355 | - |
dc.citation.title | INTERNATIONAL IMMUNOLOGY | - |
dc.citation.volume | 16 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-5044249583 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 16 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CLASS-II TRANSACTIVATOR | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | FAS LIGAND | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | IL-4 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | INTERLEUKIN-4 | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordAuthor | experimental autoimmune encephalomyelitis | - |
dc.subject.keywordAuthor | IFN-gamma | - |
dc.subject.keywordAuthor | MHC class II | - |
dc.subject.keywordAuthor | transgenic mouse | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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