DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, JH | - |
dc.contributor.author | Park, JB | - |
dc.contributor.author | Bae, SS | - |
dc.contributor.author | Yun, S | - |
dc.contributor.author | Kim, HS | - |
dc.contributor.author | Hong, WP | - |
dc.contributor.author | Kim, IS | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Han, MY | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Patterson, RL | - |
dc.contributor.author | Snyder, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-03-31T12:16:00Z | - |
dc.date.available | 2016-03-31T12:16:00Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2004-08-01 | - |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.other | 2004-OAK-0000004518 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/17729 | - |
dc.description.abstract | Phospholipase C-gamma1 (PLC-gamma1), which interacts with a variety of signaling molecules through its two Src homology (SH) 2 domains and a single SH3 domain has been implicated in the regulation of many cellular functions. We demonstrate that PLC-gamma1 acts as a guanine nucleotide exchange factor (GEF) of dynamin-1, a 100 kDa GTPase protein, which is involved in clathrin-mediated endocytosis of epidermal growth factor (EGF) receptor. Overexpression of PLC-gamma1 increases endocytosis of the EGF receptor by increasing guanine nucleotide exchange activity of dynamin-1. The GEF activity of PLC-gamma1 is mediated by the direct interaction of its SH3 domain with dynamin-1. EGF-dependent activation of ERK and serum response element (SRE) are both up-regulated in PC12 cells stably overexpressing PLC-gamma1, but knockdown of PLC-gamma1 by siRNA significantly reduces ERK activation. These results establish a new role for PLC-gamma1 in the regulation of endocytosis and suggest that endocytosis of activated EGF receptors may mediate PLC-gamma1-dependent proliferation. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | COMPANY OF BIOLOGISTS LTD | - |
dc.relation.isPartOf | JOURNAL OF CELL SCIENCE | - |
dc.subject | phospholipase C-gamma 1 | - |
dc.subject | dynamin-1 | - |
dc.subject | guanine nucleotide exchange factor (GEF) | - |
dc.subject | endocytosis | - |
dc.subject | proliferation | - |
dc.subject | COATED VESICLE FORMATION | - |
dc.subject | GTP-BINDING PROTEINS | - |
dc.subject | DBL ONCOGENE PRODUCT | - |
dc.subject | MEDIATED ENDOCYTOSIS | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | MAP KINASE | - |
dc.subject | POINT MUTATION | - |
dc.subject | SH3 DOMAINS | - |
dc.subject | RHO-GTPASES | - |
dc.subject | C-GAMMA-1 | - |
dc.title | Phospholipase C-gamma 1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1242/JCS.01220 | - |
dc.author.google | Choi, JH | - |
dc.author.google | Park, JB | - |
dc.author.google | Bae, SS | - |
dc.author.google | Yun, S | - |
dc.author.google | Kim, HS | - |
dc.author.google | Hong, WP | - |
dc.author.google | Kim, IS | - |
dc.author.google | Kim, JH | - |
dc.author.google | Han, MY | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Patterson, RL | - |
dc.author.google | Snyder, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 117 | - |
dc.relation.issue | 17 | - |
dc.relation.startpage | 3785 | - |
dc.relation.lastpage | 3795 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | JOURNAL OF CELL SCIENCE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL SCIENCE, v.117, no.17, pp.3785 - 3795 | - |
dc.identifier.wosid | 000223733100009 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 3795 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 3785 | - |
dc.citation.title | JOURNAL OF CELL SCIENCE | - |
dc.citation.volume | 117 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.identifier.scopusid | 2-s2.0-4444234130 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 39 | - |
dc.description.scptc | 40 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COATED VESICLE FORMATION | - |
dc.subject.keywordPlus | GTP-BINDING PROTEINS | - |
dc.subject.keywordPlus | DBL ONCOGENE PRODUCT | - |
dc.subject.keywordPlus | MEDIATED ENDOCYTOSIS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | POINT MUTATION | - |
dc.subject.keywordPlus | SH3 DOMAINS | - |
dc.subject.keywordPlus | RHO-GTPASES | - |
dc.subject.keywordPlus | C-GAMMA-1 | - |
dc.subject.keywordAuthor | phospholipase C-gamma 1 | - |
dc.subject.keywordAuthor | dynamin-1 | - |
dc.subject.keywordAuthor | guanine nucleotide exchange factor (GEF) | - |
dc.subject.keywordAuthor | endocytosis | - |
dc.subject.keywordAuthor | proliferation | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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