The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis
SCIE
SCOPUS
- Title
- The response regulator 2 mediates ethylene signalling and hormone signal integration in Arabidopsis
- Authors
- Hass, C; Lohrmann, J; Albrecht, V; Sweere, U; Hummel, F; Yoo, SD; Hwang, I; Zhu, T; Schafer, E; Kudla, J; Harter, K
- Date Issued
- 2004-08-18
- Publisher
- NATURE PUBLISHING GROUP
- Abstract
- Hormones are important regulators of plant growth and development. In Arabidopsis, perception of the phytohormones ethylene and cytokinin is accomplished by a family of sensor histidine kinases including ethylene-resistant (ETR) 1 and cytokinin-response (CRE) 1. We identified the Arabidopsis response regulator 2 (ARR2) as a signalling component functioning downstream of ETR1 in ethylene signal transduction. Analyses of loss-of-function and ARR2-overexpressing lines as well as functional assays in protoplasts indicate an important role of ARR2 in mediating ethylene responses. Additional investigations indicate that an ETR1-initiated phosphorelay regulates the transcription factor activity of ARR2. This mechanism may create a novel signal transfer from endoplasmic reticulum-associated ETR1 to the nucleus for the regulation of ethylene-response genes. Furthermore, global expression profiling revealed a complex ARR2-involving two-component network that interferes with a multitude of different signalling pathways and thereby contributes to the highly integrated signal processing machinery in higher plants.
- Keywords
- expression profiling; phosphorelay; phytohormone signalling; response regulator; two-component system; TRANSCRIPTION FACTOR; RECEPTOR ETR1; TRANSDUCTION; EXPRESSION; PROTEIN; KINASE; GENES; CYTOKININS; MUTATIONS; STABILITY
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/17730
- DOI
- 10.1038/SJ.EMBOJ.7600337
- ISSN
- 0261-4189
- Article Type
- Article
- Citation
- EMBO JOURNAL, vol. 23, no. 16, page. 3290 - 3302, 2004-08-18
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