Synthesis of C-1-symmetric chiral tripodal oxazolines through an oxazoline exchange reaction with amino alcohols

Abstract

Various C-1-symmetric chiral tripodal tris(oxazolines) with two different oxazoline units were synthesized from chiral C-3-symmetric tris(oxazolines) through an oxazoline exchange reaction with amino alcohols in the presence of zinc chloride. Evaluation of the new oxazolines as chiral molecular receptor showed that some of the receptors have chiral discrimination ability. (C) 2004 Elsevier Ltd. All rights reserved.