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Fluorescent oligonucleotide incorporating 5-(1-ethynylpyrenyl)2 '-deoxyuridine: sequence-specific fluorescence changes upon duplex formation SCIE SCOPUS
- Title
- Fluorescent oligonucleotide incorporating 5-(1-ethynylpyrenyl)2 '-deoxyuridine: sequence-specific fluorescence changes upon duplex formation
- Date Issued
- 2004-04-26
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- We describe the design and properties of a pyrene-labeled deoxyuridine that can be inserted efficiently into oligode-oxynucleotides using phosphoramidite chemistry. An oligonucleotide incorporating the pyrene-labeled deoxyuridine is a sensitive fluorescence probe that can discriminate between perfect and single-base-mismatched pairing by changes in its fluorescence intensity. (C) 2004 Elsevier Ltd. All rights reserved.
- Keywords
- fluorescence; nucleosides; nucleotide; INTERCALATING NUCLEIC-ACIDS; EXCIMER FLUORESCENCE; ELECTRON INJECTION; DNA; RNA; PYRENE; PROBE; HYBRIDIZATION; NUCLEOSIDE; FLUOROPHORES
- ISSN
- 0040-4039
- Article Type
- Article
- Citation
- TETRAHEDRON LETTERS, vol. 45, no. 18, page. 3543 - 3546, 2004-04-26
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Related Researcher
- 김병현KIM, BYEANG HYEAN
- Div of Advanced Materials Science